Seroatlas · Human Serome Atlas

HMG20A

High mobility group protein 20A

Also known as: FLJ10739, HM20A_HUMAN, HMGX1, HMGXB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NP66
Gene: HMG20A
Ensembl: ENSG00000140382
Chromosome: 15
Canonical length: 347 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within negative regulation of neuron differentiation; negative regulation of protein sumoylation; and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>Q9NP66|HMG20A
     1  MENLMTSSTL PPLFADEDGS KESNDLATTG LNHPEVPYSS GATSSTNNPE FVEDLSQGQL
    61  LQSESSNAAE GNEQRHEDEQ RSKRGGWSKG RKRKKPLRDS NAPKSPLTGY VRFMNERREQ
   121  LRAKRPEVPF PEITRMLGNE WSKLPPEEKQ RYLDEADRDK ERYMKELEQY QKTEAYKVFS
   181  RKTQDRQKGK SHRQDAARQA THDHEKETEV KERSVFDIPI FTEEFLNHSK AREAELRQLR
   241  KSNMEFEERN AALQKHVESM RTAVEKLEVD VIQERSRNTV LQQHLETLRQ VLTSSFASMP
   301  LPGSGETPTV DTIDSYMNRL HSIILANPQD NENFIATVRE VVNRLDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMG20A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

spleen: 34 nTPM
thymus: 29 nTPM
skeletal muscle: 26 nTPM
tongue: 25 nTPM
retina: 24 nTPM
lymph node: 24 nTPM

Single-cell type

myonuclei: 199 nCPM
sertoli cells: 139 nCPM
late spermatids: 129 nCPM
choroid plexus epithelial cells: 117 nCPM
cardiomyocytes: 109 nCPM
adrenal cortex cells: 101 nCPM

Immune cell

NK-cell: 49 nTPM
MAIT T-cell: 35 nTPM
memory B-cell: 31 nTPM
naive CD4 T-cell: 31 nTPM
gdT-cell: 29 nTPM
myeloid DC: 28 nTPM

Brain region

cerebral cortex: 54 nTPM
white matter: 52 nTPM
thalamus: 50 nTPM
cerebellum: 50 nTPM
hypothalamus: 50 nTPM
basal ganglia: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.68
gnomAD missense Z: 1.41
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HMG20A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMG20A as an antibody target. Whether an autoantibody or antibody against HMG20A could matter depends on whether native HMG20A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMG20A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HMG20A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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