Seroatlas · Human Serome Atlas

ZNF516

Zinc finger protein 516

Also known as: HsT287, KIAA0222, ZN516_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92618
Gene: ZNF516
Ensembl: ENSG00000101493
Chromosome: 18
Canonical length: 1163 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]

Canonical amino-acid sequenceUniProt

1163 residues, UniProt reviewed canonical sequence.

>Q92618|ZNF516
     1  MDRNREAEME LRRGPSPTRA GRGHEVDGDK ATCHTCCICG KSFPFQSSLS QHMRKHTGEK
    61  PYKCPYCDHR ASQKGNLKIH IRSHRTGTLI QGHEPEAGEA PLGEMRASEG LDACASPTKS
   121  ASACNRLLNG ASQADGARVL NGASQADSGR VLLRSSKKGA EGSACAPGEA KAAVQCSFCK
   181  SQFERKKDLE LHVHQAHKPF KCRLCSYATL REESLLSHIE RDHITAQGPG SGEACVENGK
   241  PELSPGEFPC EVCGQAFSQT WFLKAHMKKH RGSFDHGCHI CGRRFKEPWF LKNHMKAHGP
   301  KTGSKNRPKS ELDPIATINN VVQEEVIVAG LSLYEVCAKC GNLFTNLDSL NAHNAIHRRV
   361  EASRTRAPAE EGAEGPSDTK QFFLQCLNLR PSAAGDSCPG TQAGRRVAEL DPVNSYQAWQ
   421  LATRGKVAEP AEYLKYGAWD EALAGDVAFD KDRREYVLVS QEKRKREQDA PAAQGPPRKR
   481  ASGPGDPAPA GHLDPRSAAR PNRRAAATTG QGKSSECFEC GKIFRTYHQM VLHSRVHRRA
   541  RRERDSDGDR AARARCGSLS EGDSASQPSS PGSACAAADS PGSGLADEAA EDSGEEGAPE
   601  PAPGGQPRRC CFSEEVTSTE LSSGDQSHKM GDNASERDTG ESKAGIAASV SILENSSRET
   661  SRRQEQHRFS MDLKMPAFHP KQEVPVPGDG VEFPSSTGAE GQTGHPAEKL SDLHNKEHSG
   721  GGKRALAPDL MPLDLSARST RDDPSNKETA SSLQAALVVH PCPYCSHKTY YPEVLWMHKR
   781  IWHRVSCNSV APPWIQPNGY KSIRSNLVFL SRSGRTGPPP ALGGKECQPL LLARFTRTQV
   841  PGGMPGSKSG SSPLGVVTKA ASMPKNKESH SGGPCALWAP GPDGYRQTKP CHGQEPHGAA
   901  TQGPLAKPRQ EASSKPVPAP GGGGFSRSAT PTPTVIARAG AQPSANSKPV EKFGVPPAGA
   961  GFAPTNKHSA PDSLKAKFSA QPQGPPPAKG EGGAPPLPPR EPPSKAAQEL RTLATCAAGS
  1021  RGDAALQAQP GVAGAPPVLH SIKQEPVAEG HEKRLDILNI FKTYIPKDFA TLYQGWGVSG
  1081  PGLEHRGTLR TQARPGEFVC IECGKSFHQP GHLRAHMRAH SVVFESDGPR GSEVHTTSAD
  1141  APKQGRDHSN TGTVQTVPLR KGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF516 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

testis: 32 nTPM
endometrium: 30 nTPM
cervix: 29 nTPM
bone marrow: 23 nTPM
fallopian tube: 21 nTPM
ovary: 21 nTPM

Single-cell type

neutrophils: 677 nCPM
endometrial stromal cells: 398 nCPM
neutrophil progenitors: 334 nCPM
endometrial glandular cells: 324 nCPM
sertoli cells: 268 nCPM
lactotrophs: 258 nCPM

Immune cell

neutrophil: 10 nTPM
eosinophil: 2.9 nTPM
basophil: 2.6 nTPM
classical monocyte: 1.8 nTPM
non-classical monocyte: 1.4 nTPM
intermediate monocyte: 1.3 nTPM

Brain region

hypothalamus: 62 nTPM
amygdala: 56 nTPM
thalamus: 55 nTPM
midbrain: 55 nTPM
basal ganglia: 54 nTPM
hippocampal formation: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 0.99

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF516 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF516 as an antibody target. Whether an autoantibody or antibody against ZNF516 could matter depends on whether native ZNF516 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF516 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF516 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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