Seroatlas · Human Serome Atlas

CXXC1

CXXC-type zinc finger protein 1

Also known as: CFP1, CGBP, CXXC1_HUMAN, hCGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P0U4
Gene
CXXC1
Ensembl
ENSG00000154832
Chromosome
18
Canonical length
656 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

656 residues, UniProt reviewed canonical sequence.

>Q9P0U4|CXXC1
     1  MEGDGSDPEP PDAGEDSKSE NGENAPIYCI CRKPDINCFM IGCDNCNEWF HGDCIRITEK
    61  MAKAIREWYC RECREKDPKL EIRYRHKKSR ERDGNERDSS EPRDEGGGRK RPVPDPDLQR
   121  RAGSGTGVGA MLARGSASPH KSSPQPLVAT PSQHHQQQQQ QIKRSARMCG ECEACRRTED
   181  CGHCDFCRDM KKFGGPNKIR QKCRLRQCQL RARESYKYFP SSLSPVTPSE SLPRPRRPLP
   241  TQQQPQPSQK LGRIREDEGA VASSTVKEPP EATATPEPLS DEDLPLDPDL YQDFCAGAFD
   301  DHGLPWMSDT EESPFLDPAL RKRAVKVKHV KRREKKSEKK KEERYKRHRQ KQKHKDKWKH
   361  PERADAKDPA SLPQCLGPGC VRPAQPSSKY CSDDCGMKLA ANRIYEILPQ RIQQWQQSPC
   421  IAEEHGKKLL ERIRREQQSA RTRLQEMERR FHELEAIILR AKQQAVREDE ESNEGDSDDT
   481  DLQIFCVSCG HPINPRVALR HMERCYAKYE SQTSFGSMYP TRIEGATRLF CDVYNPQSKT
   541  YCKRLQVLCP EHSRDPKVPA DEVCGCPLVR DVFELTGDFC RLPKRQCNRH YCWEKLRRAE
   601  VDLERVRVWY KLDELFEQER NVRTAMTNRA GLLALMLHQT IQHDPLTTDL RSSADR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXXC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 63 nTPM
  • pancreas: 50 nTPM
  • bone marrow: 43 nTPM
  • spleen: 39 nTPM
  • kidney: 37 nTPM
  • skin: 37 nTPM

Single-cell type

  • tuft cells: 58 nCPM
  • early primary spermatocytes: 55 nCPM
  • extravillous trophoblasts: 50 nCPM
  • migrating cytotrophoblasts: 45 nCPM
  • syncytiotrophoblasts: 42 nCPM
  • foveolar cells: 37 nCPM

Immune cell

  • eosinophil: 34 nTPM
  • naive B-cell: 28 nTPM
  • memory B-cell: 27 nTPM
  • T-reg: 26 nTPM
  • MAIT T-cell: 25 nTPM
  • basophil: 25 nTPM

Brain region

  • cerebellum: 36 nTPM
  • choroid plexus: 28 nTPM
  • white matter: 28 nTPM
  • cerebral cortex: 28 nTPM
  • thalamus: 27 nTPM
  • basal ganglia: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.9
gnomAD missense Z
3.15
DepMap mean gene effect
-0.24
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CXXC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXXC1 as an antibody target. Whether an autoantibody or antibody against CXXC1 could matter depends on whether native CXXC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXXC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CXXC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CXXC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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