Seroatlas · Human Serome Atlas

APPBP2

Amyloid protein-binding protein 2

Also known as: APBP2_HUMAN, Hs.84084, KIAA0228, PAT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92624
Gene: APPBP2
Ensembl: ENSG00000062725
Chromosome: 17
Canonical length: 585 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>Q92624|APPBP2
     1  MAAVELEWIP ETLYNTAISA VVDNYIRSRR DIRSLPENIQ FDVYYKLYQQ GRLCQLGSEF
    61  CELEVFAKVL RALDKRHLLH HCFQALMDHG VKVASVLAYS FSRRCSYIAE SDAAVKEKAI
   121  QVGFVLGGFL SDAGWYSDAE KVFLSCLQLC TLHDEMLHWF RAVECCVRLL HVRNGNCKYH
   181  LGEETFKLAQ TYMDKLSKHG QQANKAALYG ELCALLFAKS HYDEAYKWCI EAMKEITAGL
   241  PVKVVVDVLR QASKACVVKR EFKKAEQLIK HAVYLARDHF GSKHPKYSDT LLDYGFYLLN
   301  VDNICQSVAI YQAALDIRQS VFGGKNIHVA TAHEDLAYSS YVHQYSSGKF DNALFHAERA
   361  IGIITHILPE DHLLLASSKR VKALILEEIA IDCHNKETEQ RLLQEAHDLH LSSLQLAKKA
   421  FGEFNVQTAK HYGNLGRLYQ SMRKFKEAEE MHIKAIQIKE QLLGQEDYEV ALSVGHLASL
   481  YNYDMNQYEN AEKLYLRSIA IGKKLFGEGY SGLEYDYRGL IKLYNSIGNY EKVFEYHNVL
   541  SNWNRLRDRQ YSVTDALEDV STSPQSTEEV VQSFLISQNV EGPSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APPBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

testis: 22 nTPM
cerebral cortex: 18 nTPM
ovary: 18 nTPM
retina: 16 nTPM
cerebellum: 15 nTPM
adipose tissue: 14 nTPM

Single-cell type

early spermatids: 504 nCPM
sertoli cells: 327 nCPM
podocytes: 327 nCPM
late primary spermatocytes: 220 nCPM
oligodendrocytes: 198 nCPM
adipocytes: 190 nCPM

Immune cell

basophil: 14 nTPM
NK-cell: 13 nTPM
non-classical monocyte: 12 nTPM
eosinophil: 12 nTPM
neutrophil: 12 nTPM
naive CD4 T-cell: 12 nTPM

Brain region

white matter: 44 nTPM
cerebral cortex: 35 nTPM
basal ganglia: 31 nTPM
cerebellum: 31 nTPM
spinal cord: 31 nTPM
thalamus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 1
gnomAD missense Z: 3.09
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Tetratricopeptide repeat
Amyloid protein-binding protein 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of APPBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APPBP2 as an antibody target. Whether an autoantibody or antibody against APPBP2 could matter depends on whether native APPBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APPBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APPBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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