Seroatlas · Human Serome Atlas

PEX5L

PEX5-related protein

Also known as: PEX5R, PEX5R_HUMAN, PXR2, TRIP8b

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYB4
Gene: PEX5L
Ensembl: ENSG00000114757
Chromosome: 3
Canonical length: 626 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables peroxisome matrix targeting signal-1 binding activity and small GTPase binding activity. Predicted to be involved in protein import into peroxisome matrix, docking. Predicted to act upstream of or within maintenance of protein location and regulation of membrane potential. Located in cytosol. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

626 residues, UniProt reviewed canonical sequence.

>Q8IYB4|PEX5L
     1  MYQGHMQKSK EQGYGKLSSD EDLEIIVDQK QGKGSRAADK AVAMVMKEIP REESAEEKPL
    61  LTMTSQLVNE QQESRPLLSP SIDDFLCETK SEAIARPVTS NTAVLTTGLD LLDLSEPVSQ
   121  TQTKAKKSEP SSKTSSLKKK ADGSDLISTD AEQRGQPLRV PETSSLDLDI QTQLEKWDDV
   181  KFHGDRNTKG HPMAERKSSS SRTGSKELLW SSEHRSQPEL SGGKSALNSE SASELELVAP
   241  TQARLTKEHR WGSALLSRNH SLEEEFERAK AAVESDTEFW DKMQAEWEEM ARRNWISENQ
   301  EAQNQVTISA SEKGYYFHTE NPFKDWPGAF EEGLKRLKEG DLPVTILFME AAILQDPGDA
   361  EAWQFLGITQ AENENEQAAI VALQRCLELQ PNNLKALMAL AVSYTNTGHQ QDACDALKNW
   421  IKQNPKYKYL VKSKKGSPGL TRRMSKSPVD SSVLEGVKEL YLEAAHQNGD MIDPDLQTGL
   481  GVLFHLSGEF NRAIDAFNAA LTVRPEDYSL WNRLGATLAN GDRSEEAVEA YTRALEIQPG
   541  FIRSRYNLGI SCINLGAYRE AVSNFLTALS LQRKSRNQQQ VPHPAISGNI WAALRIALSL
   601  MDQPELFQAA NLGDLDVLLR AFNLDP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PEX5L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 47 nTPM
cerebral cortex: 38 nTPM
parathyroid gland: 28 nTPM
midbrain: 26 nTPM
hippocampal formation: 23 nTPM
retina: 14 nTPM

Single-cell type

cone photoreceptor cells: 2,577 nCPM
corticotrophs: 2,464 nCPM
oligodendrocytes: 2,214 nCPM
brain excitatory neurons: 638 nCPM
somatotrophs: 556 nCPM
retinal ganglion cells: 522 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 472 nTPM
basal ganglia: 275 nTPM
medulla oblongata: 255 nTPM
pons: 253 nTPM
midbrain: 236 nTPM
cerebellum: 229 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.01
gnomAD missense Z: 2.85
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

docking
protein import into peroxisome matrix

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PEX5L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PEX5L as an antibody target. Whether an autoantibody or antibody against PEX5L could matter depends on whether native PEX5L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PEX5L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PEX5L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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