Seroatlas · Human Serome Atlas

VPS8

Vacuolar protein sorting-associated protein 8 homolog

Also known as: FLJ32099, KIAA0804, VPS8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3P4
Gene: VPS8
Ensembl: ENSG00000156931
Chromosome: 3
Canonical length: 1428 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Involved in endosomal vesicle fusion. Located in early endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1428 residues, UniProt reviewed canonical sequence.

>Q8N3P4|VPS8
     1  MENEPDHENV EQSLCAKTSE EELNKSFNLE ASLSKFSYID MDKELEFKND LIDDKEFDIP
    61  QVDTPPTLES ILNETDDEDE SFILEDPTLL NIDTIDSHSY DTSSVASSDS GDRTNLKRKK
   121  KLPDSFSLHG SVMRHSLLKG ISAQIVSAAD KVDAGLPTAI AVSSLIAVGT SHGLALIFGK
   181  DQNQALRLCL GSTSVGGQYG AISALSINND CSRLLCGFAK GQITMWDLAS GKLLRSITDA
   241  HPPGTAILHI KFTDDPTLAI CNDSGGSVFE LTFKRVMGVR TCESRCLFSG SKGEVCCIEP
   301  LHSKPELKDH PITQFSLLAM ASLTKILVIG LKPSLKVWMT FPYGRMDPSS VPLLAWHFVA
   361  VQNYVNPMLA FCRGDVVHFL LVKRDESGAI HVTKQKHLHL YYDLINFTWI NSRTVVLLDS
   421  VEKLHVIDRQ TQEELETVEI SEVQLVYNSS HFKSLATGGN VSQALALVGE KACYQSISSY
   481  GGQIFYLGTK SVYVMMLRSW RERVDHLLKQ DCLTEALALA WSFHEGKAKA VVGLSGDASK
   541  RKAIVADRMV EILFHYADRA LKKCPDQGKI QVMEQHFQDM VPVIVDYCLL LQRKDLLFSQ
   601  MYDKLSENSV AKGVFLECLE PYILSDKLVG ITPQVMKDLI VHFQDKKLME NVEALIVHMD
   661  ITSLDIQQVV LMCWENRLYD AMIYVYNRGM NEFISPMEKL FRVIAPPLNA GKTLTDEQVV
   721  MGNKLLVYIS CCLAGRAYPL GDIPEDLVPL VKNQVFEFLI RLHSAEASPE EEIYPYIRTL
   781  LHFDTREFLN VLALTFEDFK NDKQAVEYQQ RIVDILLKVM VENSDFTPSQ VGCLFTFLAR
   841  QLAKPDNTLF VNRTLFDQVL EFLCSPDDDS RHSERQQVLL ELLQAGGIVQ FEESRLIRMA
   901  EKAEFYQICE FMYEREHQYD KIIDCYLRDP LREEEVFNYI HNILSIPGHS AEEKQSVWQK
   961  AMDHIEELVS LKPCKAAELV ATHFSGHIET VIKKLQNQVL LFKFLRSLLD PREGIHVNQE
  1021  LLQISPCITE QFIELLCQFN PTQVIETLQV LECYRLEETI QITQKYQLHE VTAYLLEKKG
  1081  DIHGAFLIML ERLQSKLQEV THQGENTKED PSLKDVEDTM VETIALCQRN SHNLNQQQRE
  1141  ALWFPLLEAM MAPQKLSSSA IPHLHSEALK SLTMQVLNSM AAFIALPSIL QRILQDPVYG
  1201  KGKLGEIQGL ILGMLDTFNY EQTLLETTTS LLNQDLHWSL CNLRASVTRG LNPKQDYCSI
  1261  CLQQYKRRQE MADEIIVFSC GHLYHSFCLQ NKECTVEFEG QTRWTCYKCS SSNKVGKLSE
  1321  NSSEIKKGRI TPSQVKMSPS YHQSKGDPTA KKGTSEPVLD PQQIQAFDQL CRLYRGSSRL
  1381  ALLTELSQNR SSESYRPFSG SQSAPAFNSI FQNENFQLQL IPPPVTED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPS8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 27 nTPM
bone marrow: 22 nTPM
heart muscle: 18 nTPM
spinal cord: 18 nTPM
testis: 16 nTPM
cerebral cortex: 16 nTPM

Single-cell type

neutrophils: 1,317 nCPM
myonuclei: 633 nCPM
neutrophil progenitors: 461 nCPM
choroid plexus epithelial cells: 239 nCPM
microglia: 224 nCPM
thyrotrophs: 200 nCPM

Immune cell

neutrophil: 25 nTPM
eosinophil: 23 nTPM
basophil: 19 nTPM
myeloid DC: 8.1 nTPM
naive CD4 T-cell: 8 nTPM
classical monocyte: 6.7 nTPM

Brain region

white matter: 103 nTPM
choroid plexus: 90 nTPM
thalamus: 87 nTPM
pons: 84 nTPM
cerebellum: 83 nTPM
cerebral cortex: 78 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VPS8.

Disease | ImmuneIEDB

Conditions an epitope on VPS8 was assayed in.

lymphoid leukemia T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0
gnomAD missense Z: 1.36
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
Zinc finger, RING-type
Quinoprotein amine dehydrogenase, beta chain-like
Zinc finger, RING/FYVE/PHD-type
WD40/YVTN repeat-like-containing domain superfamily
WD40-repeat-containing domain superfamily
Vacuolar protein sorting-associated protein Vps41/Vps8
Vacuolar protein sorting-associated protein 8, central domain
Vps8, RING finger
Vps8 central TPR
Vps8 beta-propeller
Vps8 RING zinc finger

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VPS8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPS8 as an antibody target. Whether an autoantibody or antibody against VPS8 could matter depends on whether native VPS8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPS8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VPS8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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