Seroatlas · Human Serome Atlas

TGFBRAP1

Transforming growth factor-beta receptor-associated protein 1

Also known as: TGFA1_HUMAN, TRAP-1, TRAP1, VPS3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WUH2
Gene
TGFBRAP1
Ensembl
ENSG00000135966
Chromosome
2
Canonical length
860 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

860 residues, UniProt reviewed canonical sequence.

>Q8WUH2|TGFBRAP1
     1  MMSIKAFTLV SAVERELLMG DKERVNIECV ECCGRDLYVG TNDCFVYHFL LEERPVPAGP
    61  ATFTATKQLQ RHLGFKKPVN ELRAASALNR LLVLCDNSIS LVNMLNLEPV PSGARIKGAA
   121  TFALNENPVS GDPFCVEVCI ISVKRRTIQM FLVYEDRVQI VKEVSTAEQP LAVAVDGHFL
   181  CLALTTQYII HNYSTGVSQD LFPYCSEERP PIVKRIGRQE FLLAGPGGLG MFATVAGISQ
   241  RAPVHWSENV IGAAVSFPYV IALDDEFITV HSMLDQQQKQ TLPFKEGHIL QDFEGRVIVA
   301  TSKGVYILVP LPLEKQIQDL LASRRVEEAL VLAKGARRNI PKEKFQVMYR RILQQAGFIQ
   361  FAQLQFLEAK ELFRSGQLDV RELISLYPFL LPTSSSFTRS HPPLHEYADL NQLTQGDQEK
   421  MAKCKRFLMS YLNEVRSTEV ANGYKEDIDT ALLKLYAEAD HDSLLDLLVT ENFCLLTDSA
   481  AWLEKHKKYF ALGLLYHYNN QDAAAVQLWV NIVNGDVQDS TRSDLYEYIV DFLTYCLDEE
   541  LVWAYADWVL QKSEEVGVQV FTKRPLDEQQ KNSFNPDDII NCLKKYPKAL VKYLEHLVID
   601  KRLQKEEYHT HLAVLYLEEV LLQRASASGK GAEATETQAK LRRLLQKSDL YRVHFLLERL
   661  QGAGLPMESA ILHGKLGEHE KALHILVHEL QDFAAAEDYC LWCSEGRDPP HRQQLFHTLL
   721  AIYLHAGPTA HELAVAAVDL LNRHATEFDA AQVLQMLPDT WSVQLLCPFL MGAMRDSIHA
   781  RRTMQVALGL ARSENLIYTY DKMKLKGSSI QLSDKKLCQI CQNPFCEPVF VRYPNGGLVH
   841  THCAASRHTN PSSSSPGTRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TGFBRAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 21 nTPM
  • stomach: 13 nTPM
  • skeletal muscle: 11 nTPM
  • parathyroid gland: 11 nTPM
  • skin: 11 nTPM
  • thyroid gland: 10 nTPM

Single-cell type

  • hematopoietic stem cells: 84 nCPM
  • megakaryocyte-erythroid progenitors: 58 nCPM
  • parietal cells: 51 nCPM
  • neutrophil progenitors: 49 nCPM
  • lymphatic endothelial cells: 44 nCPM
  • adrenal cortex cells: 36 nCPM

Immune cell

  • gdT-cell: 1.8 nTPM
  • MAIT T-cell: 1.5 nTPM
  • memory CD4 T-cell: 1.2 nTPM
  • eosinophil: 1.1 nTPM
  • naive CD8 T-cell: 1.1 nTPM
  • memory CD8 T-cell: 1 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • white matter: 18 nTPM
  • cerebral cortex: 18 nTPM
  • hippocampal formation: 17 nTPM
  • thalamus: 17 nTPM
  • basal ganglia: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.17
gnomAD missense Z
1.36
DepMap mean gene effect
-0.28
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TGFBRAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TGFBRAP1 as an antibody target. Whether an autoantibody or antibody against TGFBRAP1 could matter depends on whether native TGFBRAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TGFBRAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TGFBRAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TGFBRAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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