Seroatlas · Human Serome Atlas

WLS

Protein wntless homolog

Also known as: C1orf139, EVI, FLJ23091, GPR177, mig-14, MRP, WLS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T9L3
Gene
WLS
Ensembl
ENSG00000116729
Chromosome
1
Canonical length
541 aa
Protein class
Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Enables Wnt-protein binding activity and identical protein binding activity. Involved in positive regulation of cell communication and protein transport. Located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum membrane. Implicated in Zaki syndrome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

541 residues, UniProt reviewed canonical sequence.

>Q5T9L3|WLS
     1  MAGAIIENMS TKKLCIVGGI LLVFQIIAFL VGGLIAPGPT TAVSYMSVKC VDARKNHHKT
    61  KWFVPWGPNH CDKIRDIEEA IPREIEANDI VFSVHIPLPH MEMSPWFQFM LFILQLDIAF
   121  KLNNQIRENA EVSMDVSLAY RDDAFAEWTE MAHERVPRKL KCTFTSPKTP EHEGRYYECD
   181  VLPFMEIGSV AHKFYLLNIR LPVNEKKKIN VGIGEIKDIR LVGIHQNGGF TKVWFAMKTF
   241  LTPSIFIIMV WYWRRITMMS RPPVLLEKVI FALGISMTFI NIPVEWFSIG FDWTWMLLFG
   301  DIRQGIFYAM LLSFWIIFCG EHMMDQHERN HIAGYWKQVG PIAVGSFCLF IFDMCERGVQ
   361  LTNPFYSIWT TDIGTELAMA FIIVAGICLC LYFLFLCFMV FQVFRNISGK QSSLPAMSKV
   421  RRLHYEGLIF RFKFLMLITL ACAAMTVIFF IVSQVTEGHW KWGGVTVQVN SAFFTGIYGM
   481  WNLYVFALMF LYAPSHKNYG EDQSNGDLGV HSGEELQLTT TITHVDGPTE IYKLTRKEAQ
   541  E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WLS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
8
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
145 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 145 nTPM
  • epididymis: 128 nTPM
  • retina: 127 nTPM
  • seminal vesicle: 96 nTPM
  • kidney: 86 nTPM
  • pancreas: 79 nTPM

Single-cell type

  • endometrial luminal cells: 552 nCPM
  • ependymal cells: 406 nCPM
  • neutrophils: 376 nCPM
  • choroid plexus epithelial cells: 330 nCPM
  • epididymal clear cells: 316 nCPM
  • rod photoreceptor cells: 273 nCPM

Immune cell

  • neutrophil: 62 nTPM
  • classical monocyte: 22 nTPM
  • intermediate monocyte: 5.4 nTPM
  • total PBMC: 4.8 nTPM
  • myeloid DC: 0.9 nTPM
  • non-classical monocyte: 0.7 nTPM

Brain region

  • thalamus: 237 nTPM
  • midbrain: 231 nTPM
  • choroid plexus: 221 nTPM
  • medulla oblongata: 191 nTPM
  • spinal cord: 174 nTPM
  • white matter: 162 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WLS.

Disease | AllUniProt

Conditions WLS is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 103 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • WLS syndrome
  • Zaki syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.02
gnomAD missense Z
0.6
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WLS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WLS as an antibody target. Whether an autoantibody or antibody against WLS could matter depends on whether native WLS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WLS is annotated at the cell surface, where native WLS is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label WLS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WLS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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