RGS4

Protein identityUniProt · HPA

UniProt accession

P49798

Gene

RGS4

Ensembl

ENSG00000117152

Chromosome

1

Canonical length

205 aa

Protein class

Disease related genes, Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>P49798|RGS4
     1  MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHN KKDKVVICQR VSQEEVKKWA
    61  ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS
   121  VQATKEVNLD SCTREETSRN MLEPTITCFD EAQKKIFNLM EKDSYRRFLK SRFYLDLVNP
   181  SSCGAEKQKG AKSSADCASL VPQCA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.46

Highest tissue expression

192 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RGS4.

Disease | AllUniProt

Conditions RGS4 is implicated in, by any mechanism.

• Schizophrenia (SCZD) MIM:181500

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.44

gnomAD pLI

0

gnomAD missense Z

0.12

DepMap mean gene effect

0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• dorsal root ganglion development
• G protein-coupled receptor signaling pathway
• negative regulation of cell growth involved in cardiac muscle cell development
• negative regulation of dopamine receptor signaling pathway
• negative regulation of glycine import across plasma membrane
• negative regulation of potassium ion transmembrane transport
• positive regulation of excitatory postsynaptic potential
• positive regulation of heart rate
• regulation of actin filament organization
• regulation of calcium ion transport
• regulation of G protein-coupled receptor signaling pathway
• response to amphetamine
• response to cocaine
• response to ethanol

Molecular functions

• calmodulin binding
• G-protein alpha-subunit binding
• GTPase activator activity
• GTPase activity
• protein kinase binding

Cellular components

• cytoplasm
• nucleus
• plasma membrane
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• RGS domain
• RGS, subdomain 1/3
• RGS domain superfamily
• RGS, subdomain 2
• Regulator of G protein signaling domain
• Regulator of G-protein signalling 4, RGS domain

KeywordsUniProt

• Lipoprotein
• Palmitate
• Phosphoprotein
• Schizophrenia
• Signal transduction inhibitor

InteractionsUniProt · HPA

Protein binding partners of RGS4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• OPRM1
• PPP1R9B
• GNAI1
• EGFR