Seroatlas · Human Serome Atlas

PYDC5

Pyrin domain-containing protein 5

Also known as: POP3, PYDC5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
W6CW81
Gene
PYDC5
Ensembl
ENSG00000289721
Chromosome
1
Canonical length
113 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Involved in cellular response to interferon-beta; cellular response to virus; and negative regulation of AIM2 inflammasome complex assembly. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>W6CW81|PYDC5
     1  MESKYKEILL LTSLDNITDE ELDRFKCFLP DEFNIATGKL HTLNSTSSQL DLKRWHGVCS
    61  EEDRIFQKLN YMLVAKCLRE EQETGICGSP SSARSVSQSR LGLSFHGISG NAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PYDC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
0.2 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 0.2 nTPM
  • lymph node: 0.1 nTPM
  • retina: 0.1 nTPM
  • spleen: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • epicardial cells: 43 nCPM
  • adipocytes: 9.4 nCPM
  • fibroblasts: 5.9 nCPM
  • vascular endothelial cells: 3.1 nCPM
  • granulosa cells: 2.4 nCPM
  • medullary thymic epithelial cells: 2.4 nCPM

Immune cell

  • gdT-cell: 0.5 nTPM
  • memory CD8 T-cell: 0.4 nTPM
  • MAIT T-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • T-reg: 0.2 nTPM
  • memory CD4 T-cell: 0.1 nTPM

Brain region

  • medulla oblongata: 2.6 nTPM
  • white matter: 2.6 nTPM
  • hypothalamus: 2.5 nTPM
  • cerebellum: 2.3 nTPM
  • cerebral cortex: 2.2 nTPM
  • basal ganglia: 2.1 nTPM

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PYDC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PYDC5 as an antibody target. Whether an autoantibody or antibody against PYDC5 could matter depends on whether native PYDC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PYDC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PYDC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PYDC5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...