Seroatlas · Human Serome Atlas

ABHD8

Protein ABHD8

Also known as: ABHD8_HUMAN, FLJ11743, MGC14280, MGC2512

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96I13
Gene: ABHD8
Ensembl: ENSG00000127220
Chromosome: 19
Canonical length: 439 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene is upstream of, and in a head-to-head orientation with the gene for the mitochondrial ribosomal protein L34. The predicted protein contains alpha/beta hydrolase fold and secretory lipase domains. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>Q96I13|ABHD8
     1  MLTGVTDGIF CCLLGTPPNA VGPLESVESS DGYTFVEVKP GRVLRVKHAG PAPAAAPPPP
    61  SSASSDAAQG DLSGLVRCQR RITVYRNGRL LVENLGRAPR ADLLHGQNGS GEPPAALEVE
   121  LADPAGSDGR LAPGSAGSGS GSGSGGRRRR ARRPKRTIHI DCEKRITSCK GAQADVVLFF
   181  IHGVGGSLAI WKEQLDFFVR LGYEVVAPDL AGHGASSAPQ VAAAYTFYAL AEDMRAIFKR
   241  YAKKRNVLIG HSYGVSFCTF LAHEYPDLVH KVIMINGGGP TALEPSFCSI FNMPTCVLHC
   301  LSPCLAWSFL KAGFARQGAK EKQLLKEGNA FNVSSFVLRA MMSGQYWPEG DEVYHAELTV
   361  PVLLVHGMHD KFVPVEEDQR MAEILLLAFL KLIDEGSHMV MLECPETVNT LLHEFLLWEP
   421  EPSPKALPEP LPAPPEDKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 99 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 99 nTPM
amygdala: 66 nTPM
hippocampal formation: 63 nTPM
basal ganglia: 62 nTPM
cerebellum: 54 nTPM
hypothalamus: 46 nTPM

Single-cell type

late spermatids: 496 nCPM
cardiomyocytes: 255 nCPM
late primary spermatocytes: 202 nCPM
early spermatids: 148 nCPM
cone photoreceptor cells: 85 nCPM
rod photoreceptor cells: 77 nCPM

Immune cell

eosinophil: 3 nTPM
myeloid DC: 2.9 nTPM
classical monocyte: 2.4 nTPM
intermediate monocyte: 1.9 nTPM
non-classical monocyte: 1.9 nTPM
NK-cell: 1.7 nTPM

Brain region

cerebral cortex: 113 nTPM
hippocampal formation: 86 nTPM
basal ganglia: 84 nTPM
amygdala: 78 nTPM
thalamus: 77 nTPM
midbrain: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.97
gnomAD missense Z: 1.8
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABHD8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD8 as an antibody target. Whether an autoantibody or antibody against ABHD8 could matter depends on whether native ABHD8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABHD8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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