SH3BGRL3
SH3 domain-binding glutamic acid-rich-like protein 3
Also known as: SH3L3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H299
- Gene
- SH3BGRL3
- Ensembl
- ENSG00000142669
- Chromosome
- 1
- Canonical length
- 93 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nuclear bodies
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Involved in cytoskeleton organization. Located in cytosol; nuclear body; and ruffle membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
93 residues, UniProt reviewed canonical sequence.
>Q9H299|SH3BGRL3
1 MSGLRVYSTS VTGSREIKSQ QSEVTRILDG KRIQYQLVDI SQDNALRDEM RALAGNPKAT
61 PPQIVNGDQY CGDYELFVEA VEQNTLQEFL KLALocalizationUniProt · AlphaFold · HPA
Whether an antibody against SH3BGRL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 668 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 668 nTPM
- esophagus: 647 nTPM
- spleen: 536 nTPM
- bone marrow: 500 nTPM
- blood vessel: 483 nTPM
- rectum: 411 nTPM
Single-cell type
- platelets: 11,941 nCPM
- megakaryocytes: 6,058 nCPM
- esophageal apical cells: 5,483 nCPM
- esophageal suprabasal cells: 3,162 nCPM
- monocytes: 2,334 nCPM
- hofbauer cells: 2,084 nCPM
Immune cell
- total PBMC: 13,051 nTPM
- neutrophil: 7,796 nTPM
- classical monocyte: 7,104 nTPM
- eosinophil: 6,447 nTPM
- intermediate monocyte: 6,258 nTPM
- non-classical monocyte: 6,224 nTPM
Brain region
- thalamus: 290 nTPM
- midbrain: 259 nTPM
- white matter: 226 nTPM
- hypothalamus: 218 nTPM
- pons: 218 nTPM
- medulla oblongata: 207 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.06
- gnomAD pLI
- 0.15
- gnomAD missense Z
- 0.27
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SH3BGRL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SH3BGRL3 as an antibody target. Whether an autoantibody or antibody against SH3BGRL3 could matter depends on whether native SH3BGRL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SH3BGRL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SH3BGRL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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