LLPH
Protein LLP homolog
Also known as: C12orf31, hLLP, LLPH_HUMAN, MGC14817
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BRT6
- Gene
- LLPH
- Ensembl
- ENSG00000139233
- Chromosome
- 12
- Canonical length
- 129 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoli,Mitotic chromosome
OverviewNCBI Gene
Enables RNA binding activity. Predicted to be involved in dendrite extension and positive regulation of dendritic spine development. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
129 residues, UniProt reviewed canonical sequence.
>Q9BRT6|LLPH
1 MAKSLRSKWK RKMRAEKRKK NAPKEASRLK SILKLDGDVL MKDVQEIATV VVPKPKHCQE
61 KMQCEVKDEK DDMKMETDIK RNKKTLLDQH GQYPIWMNQR QRKRLKAKRE KRKGKSKAKA
121 VKVAKGLAWLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LLPH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 47 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 47 nTPM
- adrenal gland: 32 nTPM
- skeletal muscle: 28 nTPM
- urinary bladder: 26 nTPM
- lymph node: 25 nTPM
- tonsil: 24 nTPM
Single-cell type
- late primary spermatocytes: 182 nCPM
- esophageal suprabasal cells: 88 nCPM
- esophageal basal cells: 88 nCPM
- migrating cytotrophoblasts: 81 nCPM
- extravillous trophoblasts: 80 nCPM
- syncytiotrophoblasts: 78 nCPM
Immune cell
- non-classical monocyte: 48 nTPM
- neutrophil: 43 nTPM
- T-reg: 39 nTPM
- intermediate monocyte: 37 nTPM
- eosinophil: 35 nTPM
- basophil: 34 nTPM
Brain region
- midbrain: 16 nTPM
- cerebral cortex: 16 nTPM
- white matter: 15 nTPM
- medulla oblongata: 15 nTPM
- hypothalamus: 15 nTPM
- pons: 15 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.05
- gnomAD pLI
- 0.35
- gnomAD missense Z
- -0.26
- DepMap mean gene effect
- -0.42
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- RNA binding
- basal RNA polymerase II transcription machinery binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- LLP homolog-like
- LLP homolog
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of LLPH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LLPH as an antibody target. Whether an autoantibody or antibody against LLPH could matter depends on whether native LLPH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LLPH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LLPH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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