BOK
Bcl-2-related ovarian killer protein
Also known as: BCL2L9, BOK_HUMAN, BOKL, MGC4631
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UMX3
- Gene
- BOK
- Ensembl
- ENSG00000176720
- Chromosome
- 2
- Canonical length
- 212 aa
- Protein class
- Plasma proteins, Predicted membrane proteins, Transporters
- Quaternary structure
- Homodimer
OverviewNCBI Gene
The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]
Canonical amino-acid sequenceUniProt
212 residues, UniProt reviewed canonical sequence.
>Q9UMX3|BOK
1 MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW SAPERAAPVP
61 GRLAEVCAVL LRLGDELEMI RPSVYRNVAR QLHISLQSEP VVTDAFLAVA GHIFSAGITW
121 GKVVSLYAVA AGLAVDCVRQ AQPAMVHALV DCLGEFVRKT LATWLRRRGG WTDVLKCVVS
181 TDPGLRSHWL VAALCSFGRF LKAAFFVLLP ERLocalizationUniProt · AlphaFold · HPA
Whether an antibody against BOK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 116 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 116 nTPM
- liver: 96 nTPM
- adipose tissue: 85 nTPM
- midbrain: 63 nTPM
- hippocampal formation: 46 nTPM
- hypothalamus: 38 nTPM
Single-cell type
- hepatocytes: 122 nCPM
- oligodendrocytes: 80 nCPM
- esophageal apical cells: 76 nCPM
- alveolar cells type 1: 65 nCPM
- esophageal suprabasal cells: 63 nCPM
- epididymal principal cells: 46 nCPM
Immune cell
- gdT-cell: 2.3 nTPM
- naive CD8 T-cell: 1.1 nTPM
- memory CD8 T-cell: 1 nTPM
- memory CD4 T-cell: 0.7 nTPM
- NK-cell: 0.7 nTPM
- total PBMC: 0.6 nTPM
Brain region
- white matter: 367 nTPM
- medulla oblongata: 235 nTPM
- basal ganglia: 213 nTPM
- cerebral cortex: 179 nTPM
- midbrain: 177 nTPM
- pons: 166 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.02
- gnomAD pLI
- 0.16
- gnomAD missense Z
- 0.14
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- apoptotic process
- cellular component disassembly involved in execution phase of apoptosis
- extrinsic apoptotic signaling pathway in absence of ligand
- intrinsic apoptotic signaling pathway by p53 class mediator
- intrinsic apoptotic signaling pathway in response to DNA damage
- male gonad development
- negative regulation of mitochondrial depolarization
- negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
- negative regulation of necroptotic process
- negative regulation of neuron apoptotic process
- neuron apoptotic process
- oligodendrocyte differentiation
- positive regulation of apoptotic process
- positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
- positive regulation of execution phase of apoptosis
- positive regulation of intrinsic apoptotic signaling pathway
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
- positive regulation of PERK-mediated unfolded protein response
- protein complex oligomerization
- regulation of autophagy
- regulation of chorionic trophoblast cell proliferation
- regulation of cytosolic calcium ion concentration
- regulation of granulosa cell apoptotic process
- release of cytochrome c from mitochondria
- response to cisplatin
Molecular functions
- BH domain binding
- channel activity
- protein heterodimerization activity
- protein homodimerization activity
- protein-containing complex binding
- signaling receptor binding
- ubiquitin protein ligase binding
Cellular components
- cis-Golgi network membrane
- cytoplasm
- early endosome membrane
- endoplasmic reticulum
- endoplasmic reticulum membrane
- Golgi apparatus
- membrane
- mitochondrial inner membrane
- mitochondrial membrane
- mitochondrial outer membrane
- mitochondrion
- nuclear outer membrane
- nucleus
- recycling endosome membrane
- trans-Golgi network membrane
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of BOK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads BOK as an antibody target. Whether an autoantibody or antibody against BOK could matter depends on whether native BOK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
BOK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label BOK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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