Seroatlas · Human Serome Atlas

GRB10

Growth factor receptor-bound protein 10

Also known as: GRB10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13322
Gene: GRB10
Ensembl: ENSG00000106070
Chromosome: 7
Canonical length: 594 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

594 residues, UniProt reviewed canonical sequence.

>Q13322|GRB10
     1  MALAGCPDSF LHHPYYQDKV EQTPRSQQDP AGPGLPAQSD RLANHQEDDV DLEALVNDMN
    61  ASLESLYSAC SMQSDTVPLL QNGQHARSQP RASGPPRSIQ PQVSPRQRVQ RSQPVHILAV
   121  RRLQEEDQQF RTSSLPAIPN PFPELCGPGS PPVLTPGSLP PSQAAAKQDV KVFSEDGTSK
   181  VVEILADMTA RDLCQLLVYK SHCVDDNSWT LVEHHPHLGL ERCLEDHELV VQVESTMASE
   241  SKFLFRKNYA KYEFFKNPMN FFPEQMVTWC QQSNGSQTQL LQNFLNSSSC PEIQGFLHVK
   301  ELGKKSWKKL YVCLRRSGLY CSTKGTSKEP RHLQLLADLE DSNIFSLIAG RKQYNAPTDH
   361  GLCIKPNKVR NETKELRLLC AEDEQTRTCW MTAFRLLKYG MLLYQNYRIP QQRKALLSPF
   421  STPVRSVSEN SLVAMDFSGQ TGRVIENPAE AQSAALEEGH AWRKRSTRMN ILGSQSPLHP
   481  STLSTVIHRT QHWFHGRISR EESHRIIKQQ GLVDGLFLLR DSQSNPKAFV LTLCHHQKIK
   541  NFQILPCEDD GQTFFSLDDG NTKFSDLIQL VDFYQLNKGV LPCKLKHHCI RVAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRB10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 89 nTPM

Expression across tissuesHPA

Tissue

pancreas: 89 nTPM
retina: 77 nTPM
tongue: 71 nTPM
skeletal muscle: 54 nTPM
cerebellum: 36 nTPM
spleen: 35 nTPM

Single-cell type

neutrophils: 1,212 nCPM
pancreatic acinar cells: 743 nCPM
cone photoreceptor cells: 691 nCPM
rod photoreceptor cells: 653 nCPM
vascular endothelial cells: 442 nCPM
proximal tubule cells: 364 nCPM

Immune cell

basophil: 10 nTPM
eosinophil: 3 nTPM
neutrophil: 0.5 nTPM
memory CD4 T-cell: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM

Brain region

hypothalamus: 105 nTPM
midbrain: 93 nTPM
pons: 90 nTPM
thalamus: 80 nTPM
basal ganglia: 74 nTPM
white matter: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.94
gnomAD missense Z: 1.53
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GRB10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRB10 as an antibody target. Whether an autoantibody or antibody against GRB10 could matter depends on whether native GRB10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRB10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GRB10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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