Seroatlas · Human Serome Atlas

ZFP91

E3 ubiquitin-protein ligase ZFP91

Also known as: PZF, ZFP91_HUMAN, ZNF757

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96JP5
Gene: ZFP91
Ensembl: ENSG00000186660
Chromosome: 11
Canonical length: 570 aa
Protein class: Enzymes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

570 residues, UniProt reviewed canonical sequence.

>Q96JP5|ZFP91
     1  MPGETEEPRP PEQQDQEGGE AAKAAPEEPQ QRPPEAVAAA PAGTTSSRVL RGGRDRGRAA
    61  AAAAAAAVSR RRKAEYPRRR RSSPSARPPD VPGQQPQAAK SPSPVQGKKS PRLLCIEKVT
   121  TDKDPKEEKE EEDDSALPQE VSIAASRPSR GWRSSRTSVS RHRDTENTRS SRSKTGSLQL
   181  ICKSEPNTDQ LDYDVGEEHQ SPGGISSEEE EEEEEEMLIS EEEIPFKDDP RDETYKPHLE
   241  RETPKPRRKS GKVKEEKEKK EIKVEVEVEV KEEENEIRED EEPPRKRGRR RKDDKSPRLP
   301  KRRKKPPIQY VRCEMEGCGT VLAHPRYLQH HIKYQHLLKK KYVCPHPSCG RLFRLQKQLL
   361  RHAKHHTDQR DYICEYCARA FKSSHNLAVH RMIHTGEKPL QCEICGFTCR QKASLNWHMK
   421  KHDADSFYQF SCNICGKKFE KKDSVVAHKA KSHPEVLIAE ALAANAGALI TSTDILGTNP
   481  ESLTQPSDGQ GLPLLPEPLG NSTSGECLLL EAEGMSKSYC SGTERVSLMA DGKIFVGSGS
   541  SGGTEGLVMN SDILGATTEV LIEDSDSAGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP91 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 81 nTPM

Expression across tissuesHPA

Tissue

testis: 81 nTPM
bone marrow: 56 nTPM
skeletal muscle: 50 nTPM
tongue: 42 nTPM
thymus: 34 nTPM
rectum: 32 nTPM

Single-cell type

late spermatids: 13 nCPM
late primary spermatocytes: 7.6 nCPM
early spermatids: 6.6 nCPM
parietal cells: 5.3 nCPM
endometrial secretory cells: 5.2 nCPM
suprabasal keratinocytes: 3.6 nCPM

Immune cell

plasmacytoid DC: 2 nTPM
gdT-cell: 1.5 nTPM
neutrophil: 1.5 nTPM
classical monocyte: 1.4 nTPM
myeloid DC: 1.4 nTPM
basophil: 1.3 nTPM

Brain region

white matter: 61 nTPM
basal ganglia: 60 nTPM
spinal cord: 55 nTPM
thalamus: 54 nTPM
midbrain: 53 nTPM
amygdala: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 1.63
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFP91 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP91 as an antibody target. Whether an autoantibody or antibody against ZFP91 could matter depends on whether native ZFP91 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP91 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP91 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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