Seroatlas · Human Serome Atlas

TMEM175

Endosomal/lysosomal proton channel TMEM175

Also known as: MGC4618, TM175_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BSA9
Gene
TMEM175
Ensembl
ENSG00000127419
Chromosome
4
Canonical length
504 aa
Protein class
Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Nuclear membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables arachidonate binding activity; potassium ion leak channel activity; and proton channel activity. Involved in lysosomal lumen pH elevation; potassium ion transmembrane transport; and proton transmembrane transport. Located in endosome membrane and lysosome. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>Q9BSA9|TMEM175
     1  MSQPRTPEQA LDTPGDCPPG RRDEDAGEGI QCSQRMLSFS DALLSIIATV MILPVTHTEI
    61  SPEQQFDRSV QRLLATRIAV YLMTFLIVTV AWAAHTRLFQ VVGKTDDTLA LLNLACMMTI
   121  TFLPYTFSLM VTFPDVPLGI FLFCVCVIAI GVVQALIVGY AFHFPHLLSP QIQRSAHRAL
   181  YRRHVLGIVL QGPALCFAAA IFSLFFVPLS YLLMVTVILL PYVSKVTGWC RDRLLGHREP
   241  SAHPVEVFSF DLHEPLSKER VEAFSDGVYA IVATLLILDI CEDNVPDPKD VKERFSGSLV
   301  AALSATGPRF LAYFGSFATV GLLWFAHHSL FLHVRKATRA MGLLNTLSLA FVGGLPLAYQ
   361  QTSAFARQPR DELERVRVSC TIIFLASIFQ LAMWTTALLH QAETLQPSVW FGGREHVLMF
   421  AKLALYPCAS LLAFASTCLL SRFSVGIFHL MQIAVPCAFL LLRLLVGLAL ATLRVLRGLA
   481  RPEHPPPAPT GQDDPQSQLL PAPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM175 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 38 nTPM
  • liver: 34 nTPM
  • pituitary gland: 32 nTPM
  • cerebral cortex: 30 nTPM
  • basal ganglia: 29 nTPM
  • adrenal gland: 28 nTPM

Single-cell type

  • brain excitatory neurons: 54 nCPM
  • brain inhibitory neurons: 51 nCPM
  • breast lactating cells: 47 nCPM
  • bergmann glia: 47 nCPM
  • müller glia: 45 nCPM
  • other brain neurons: 45 nCPM

Immune cell

  • plasmacytoid DC: 47 nTPM
  • intermediate monocyte: 41 nTPM
  • non-classical monocyte: 40 nTPM
  • basophil: 37 nTPM
  • classical monocyte: 32 nTPM
  • myeloid DC: 30 nTPM

Brain region

  • cerebellum: 34 nTPM
  • pons: 33 nTPM
  • medulla oblongata: 33 nTPM
  • cerebral cortex: 30 nTPM
  • midbrain: 30 nTPM
  • white matter: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMEM175.

Disease | AllUniProt

Conditions TMEM175 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
-0.55
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Endosomal/lysosomal proton channel TMEM175-like
  • Endosomal/lysosomal potassium channel TMEM175

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM175 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM175 as an antibody target. Whether an autoantibody or antibody against TMEM175 could matter depends on whether native TMEM175 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM175 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM175 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM175. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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