Lysosome-associated membrane glycoprotein 2-like, luminal domains

Definition

This domain is found in a group of animal proteins that includes Lysosome-associated membrane glycoprotein 2 from humans (Lamp2). Lamp2 is an integral membrane protein that plays an important role in chaperone-mediated autophagy (CMA), targeting pertinent proteins for lysosomal degradation. This protein is organised into two conserved luminal domains (this entry), a single transmembrane (TM) domain ([interpro:IPR048524]), and a short C-terminal cytosolic tail. It adopts a trimeric configuration PMID:25342746.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• CD68
• LAMP1
• LAMP2
• LAMP3
• LAMP5