TMEM192
Transmembrane protein 192
Also known as: FLJ38482, TM192_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IY95
- Gene
- TMEM192
- Ensembl
- ENSG00000170088
- Chromosome
- 4
- Canonical length
- 271 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Nucleoplasm,Endosomes,Lysosomes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables protein homodimerization activity. Located in several cellular components, including late endosome; lysosomal membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
271 residues, UniProt reviewed canonical sequence.
>Q8IY95|TMEM192
1 MAAGGRMEDG SLDITQSIED DPLLDAQLLP HHSLQAHFRP RFHPLPTVII VNLLWFIHLV
61 FVVLAFLTGV LCSYPNPNED KCPGNYTNPL KVQTVIILGK VILWILHLLL ECYIQYHHSK
121 IRNRGYNLIY RSTRHLKRLA LMIQSSGNTV LLLILCMQHS FPEPGRLYLD LILAILALEL
181 ICSLICLLIY TVKIRRFNKA KPEPDILEEE KIYAYPSNIT SETGFRTISS LEEIVEKQGD
241 TIEYLKRHNA LLSKRLLALT SSDLGCQPSR TLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM192 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 45 nTPM
Expression across tissuesHPA
Tissue
- kidney: 45 nTPM
- liver: 42 nTPM
- thyroid gland: 25 nTPM
- parathyroid gland: 23 nTPM
- pancreas: 21 nTPM
- prostate: 21 nTPM
Single-cell type
- retinal pigment epithelial cells: 456 nCPM
- hepatocytes: 112 nCPM
- prostatic glandular cells: 93 nCPM
- ovarian stromal cells: 82 nCPM
- proximal tubule cells: 80 nCPM
- epididymal efferent duct absorptive cells: 76 nCPM
Immune cell
- memory B-cell: 27 nTPM
- naive B-cell: 20 nTPM
- NK-cell: 19 nTPM
- classical monocyte: 17 nTPM
- MAIT T-cell: 16 nTPM
- plasmacytoid DC: 16 nTPM
Brain region
- cerebellum: 24 nTPM
- choroid plexus: 23 nTPM
- white matter: 21 nTPM
- midbrain: 20 nTPM
- basal ganglia: 20 nTPM
- cerebral cortex: 19 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.29
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.08
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- TMEM192 family
- TMEM192 family
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TMEM192 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM192 as an antibody target. Whether an autoantibody or antibody against TMEM192 could matter depends on whether native TMEM192 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM192 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM192 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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