Seroatlas · Human Serome Atlas

NUSAP1

Nucleolar and spindle-associated protein 1

Also known as: ANKT, BM037, FLJ13421, LNP, NUSAP_HUMAN, PRO0310p1, Q0310, SAPL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXS6
Gene
NUSAP1
Ensembl
ENSG00000137804
Chromosome
15
Canonical length
441 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli fibrillar center

OverviewNCBI Gene

NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>Q9BXS6|NUSAP1
     1  MIIPSLEELD SLKYSDLQNL AKSLGLRANL RATKLLKALK GYIKHEARKG NENQDESQTS
    61  ASSCDETEIQ ISNQEEAERQ PLGHVTKTRR RCKTVRVDPD SQQNHSEIKI SNPTEFQNHE
   121  KQESQDLRAT AKVPSPPDEH QEAENAVSSG NRDSKVPSEG KKSLYTDESS KPGKNKRTAI
   181  TTPNFKKLHE AHFKEMESID QYIERKKKHF EEHNSMNELK QQPINKGGVR TPVPPRGRLS
   241  VASTPISQRR SQGRSCGPAS QSTLGLKGSL KRSAISAAKT GVRFSAATKD NEHKRSLTKT
   301  PARKSAHVTV SGGTPKGEAV LGTHKLKTIT GNSAAVITPF KLTTEATQTP VSNKKPVFDL
   361  KASLSRPLNY EPHKGKLKPW GQSKENNYLN QHVNRINFYK KTYKQPHLQT KEEQRKKREQ
   421  ERKEKKAKVL GMRRGLILAE D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUSAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
95 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 95 nTPM
  • bone marrow: 84 nTPM
  • tonsil: 30 nTPM
  • lymph node: 27 nTPM
  • esophagus: 17 nTPM
  • adrenal gland: 14 nTPM

Single-cell type

  • enteric transient amplifying cells: 18 nCPM
  • monocyte progenitors: 12 nCPM
  • erythrocyte progenitors: 12 nCPM
  • paneth cells: 12 nCPM
  • extravillous trophoblasts: 9.2 nCPM
  • gastric progenitor cells: 7.7 nCPM

Immune cell

  • basophil: 11 nTPM
  • T-reg: 7.7 nTPM
  • memory CD4 T-cell: 0.6 nTPM
  • naive B-cell: 0.6 nTPM
  • eosinophil: 0.5 nTPM
  • memory CD8 T-cell: 0.5 nTPM

Brain region

  • pons: 0.7 nTPM
  • cerebral cortex: 0.6 nTPM
  • thalamus: 0.6 nTPM
  • cerebellum: 0.5 nTPM
  • choroid plexus: 0.5 nTPM
  • medulla oblongata: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NUSAP1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 85 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.05
gnomAD missense Z
0.63
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Nucleolar and spindle-associated protein 1
  • Nucleolar and spindle-associated protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUSAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUSAP1 as an antibody target. Whether an autoantibody or antibody against NUSAP1 could matter depends on whether native NUSAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUSAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUSAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUSAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...