Seroatlas · Human Serome Atlas

BRI3

Membrane protein BRI3

Also known as: BRI3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95415
Gene: BRI3
Ensembl: ENSG00000164713
Chromosome: 7
Canonical length: 125 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be located in azurophil granule membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>O95415|BRI3
     1  MDHKPLLQER PPAYNLEAGQ GDYACGPHGY GAIPAAPPPP PYPYLVTGIP THHPRVYNIH
    61  SRTVTRYPAN SIVVVGGCPV CRVGVLEDCF TFLGIFLAII LFPFGFICCF ALRKRRCPNC
   121  GATFA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRI3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 216 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 216 nTPM
liver: 154 nTPM
lung: 149 nTPM
adrenal gland: 142 nTPM
heart muscle: 140 nTPM
stomach: 130 nTPM

Single-cell type

neutrophils: 1,042 nCPM
hofbauer cells: 909 nCPM
early spermatids: 688 nCPM
alveolar cells type 2: 686 nCPM
kupffer cells: 592 nCPM
extravillous trophoblasts: 590 nCPM

Immune cell

neutrophil: 43 nTPM
intermediate monocyte: 25 nTPM
eosinophil: 24 nTPM
non-classical monocyte: 24 nTPM
classical monocyte: 15 nTPM
plasmacytoid DC: 10 nTPM

Brain region

thalamus: 101 nTPM
choroid plexus: 83 nTPM
cerebral cortex: 77 nTPM
medulla oblongata: 76 nTPM
white matter: 76 nTPM
pons: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0.03
gnomAD missense Z: 0.11
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Membrane protein BRI3
Brain protein I3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BRI3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRI3 as an antibody target. Whether an autoantibody or antibody against BRI3 could matter depends on whether native BRI3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRI3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BRI3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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