ATP6V0B

Protein identityUniProt · HPA

UniProt accession

Q99437

Gene

ATP6V0B

Ensembl

ENSG00000117410

Chromosome

1

Canonical length

205 aa

Protein class

Metabolic proteins, Predicted membrane proteins

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q99437|ATP6V0B
     1  MTGLALLYSG VFVAFWACAL AVGVCYTIFD LGFRFDVAWF LTETSPFMWS NLGIGLAISL
    61  SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV AIYGIIMAIV ISNMAEPFSA
   121  TDPKAIGHRN YHAGYSMFGA GLTVGLSNLF CGVCVGIVGS GAALADAQNP SLFVKILIVE
   181  IFGSAIGLFG VIVAILQTSR VKMGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP6V0B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

5

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

362 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.28

gnomAD pLI

0.97

gnomAD missense Z

1.81

DepMap mean gene effect

-1.19

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• endosomal lumen acidification
• Golgi lumen acidification
• intracellular pH reduction
• lysosomal lumen acidification
• proton transmembrane transport
• regulation of macroautophagy
• vacuolar acidification

Molecular functions

• rotational mechanism
• proton-transporting ATPase activity

Cellular components

• clathrin-coated vesicle membrane
• endosome membrane
• Golgi membrane
• lysosomal membrane
• membrane
• phagocytic vesicle membrane
• plasma membrane
• proton-transporting V-type ATPase complex
• vacuolar proton-transporting V-type ATPase, V0 domain

Protein domainsUniProt · Pfam · InterPro

• V-ATPase proteolipid subunit
• V-ATPase proteolipid subunit C-like domain
• F/V-ATP synthase subunit C superfamily
• ATP synthase subunit C

KeywordsUniProt

• Cytoplasmic vesicle
• Hydrogen ion transport
• Ion transport
• Membrane
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of ATP6V0B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IFITM3
• TM4SF19