Seroatlas · Human Serome Atlas

DNLZ

DNL-type zinc finger protein

Also known as: bA413M3.2, C9orf151, DNLZ_HUMAN, HEP, RP11-413M3.2, TIMM15, ZIM17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SXM8
Gene: DNLZ
Ensembl: ENSG00000213221
Chromosome: 9
Canonical length: 178 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables protein folding chaperone. Involved in chaperone-mediated protein complex assembly. Located in nucleoplasm. Is active in cytosol; mitochondrion; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

178 residues, UniProt reviewed canonical sequence.

>Q5SXM8|DNLZ
     1  MLRTALRGAP RLLSRVQPRA PCLRRLWGRG ARPEVAGRRR AWAWGWRRSS SEQGPGPAAA
    61  LGRVEAAHYQ LVYTCKVCGT RSSKRISKLA YHQGVVIVTC PGCQNHHIIA DNLGWFSDLN
   121  GKRNIEEILT ARGEQVHRVA GEGALELVLE AAGAPTSTAA PEAGEDEGPP SPGKTEPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNLZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 6.5 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 6.5 nTPM
pancreas: 5.2 nTPM
skeletal muscle: 3.9 nTPM
amygdala: 3.6 nTPM
kidney: 3.6 nTPM
blood vessel: 3.5 nTPM

Single-cell type

epididymal principal cells: 12 nCPM
adrenal medulla cells: 11 nCPM
epididymal clear cells: 6.1 nCPM
respiratory ionocytes: 5.1 nCPM
fallopian secretory cells: 4.8 nCPM
epididymal efferent duct absorptive cells: 4 nCPM

Immune cell

memory B-cell: 1.3 nTPM
T-reg: 0.8 nTPM
basophil: 0.7 nTPM
MAIT T-cell: 0.7 nTPM
memory CD8 T-cell: 0.7 nTPM
memory CD4 T-cell: 0.6 nTPM

Brain region

cerebellum: 4.2 nTPM
white matter: 4 nTPM
basal ganglia: 3.8 nTPM
pons: 3.7 nTPM
thalamus: 3.5 nTPM
cerebral cortex: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -0.87
DepMap mean gene effect: -0.43
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, DNL-type
Mitochondrial import protein TIM15
DNL zinc finger

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNLZ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HSPA9

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNLZ as an antibody target. Whether an autoantibody or antibody against DNLZ could matter depends on whether native DNLZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNLZ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNLZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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