Seroatlas · Human Serome Atlas

GRPEL1

GrpE protein homolog 1, mitochondrial

Also known as: FLJ25609, GrpE, GRPE1_HUMAN, hMGE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HAV7
Gene: GRPEL1
Ensembl: ENSG00000109519
Chromosome: 4
Canonical length: 217 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables identical protein binding activity and unfolded protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrial matrix and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>Q9HAV7|GRPEL1
     1  MAAQCVRLAR RSLPALALSL RPSPRLLCTA TKQKNSGQNL EEDMGQSEQK ADPPATEKTL
    61  LEEKVKLEEQ LKETVEKYKR ALADTENLRQ RSQKLVEEAK LYGIQAFCKD LLEVADVLEK
   121  ATQCVPKEEI KDDNPHLKNL YEGLVMTEVQ IQKVFTKHGL LKLNPVGAKF DPYEHEALFH
   181  TPVEGKEPGT VALVSKVGYK LHGRTLRPAL VGVVKEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRPEL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 36 nTPM
liver: 29 nTPM
skeletal muscle: 27 nTPM
tongue: 26 nTPM
bone marrow: 22 nTPM
heart muscle: 22 nTPM

Single-cell type

esophageal apical cells: 279 nCPM
oocytes: 230 nCPM
esophageal suprabasal cells: 171 nCPM
esophageal basal cells: 149 nCPM
hepatocytes: 126 nCPM
late spermatids: 125 nCPM

Immune cell

eosinophil: 39 nTPM
myeloid DC: 35 nTPM
MAIT T-cell: 30 nTPM
naive CD4 T-cell: 30 nTPM
intermediate monocyte: 27 nTPM
total PBMC: 26 nTPM

Brain region

white matter: 11 nTPM
choroid plexus: 11 nTPM
pons: 10 nTPM
cerebellum: 9.6 nTPM
spinal cord: 9.3 nTPM
thalamus: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.14
gnomAD missense Z: -0.01
DepMap mean gene effect: -1.35
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GRPEL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HSPA9

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRPEL1 as an antibody target. Whether an autoantibody or antibody against GRPEL1 could matter depends on whether native GRPEL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRPEL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GRPEL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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