Seroatlas · Human Serome Atlas

TESPA1

Protein TESPA1

Also known as: ITPRID3, KIAA0748, TESP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A2RU30
Gene
TESPA1
Ensembl
ENSG00000135426
Chromosome
12
Canonical length
521 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to enable phospholipase binding activity and signaling receptor binding activity. Predicted to be involved in COP9 signalosome assembly; positive regulation of T cell differentiation in thymus; and positive regulation of T cell receptor signaling pathway. Predicted to act upstream of or within TCR signalosome assembly. Located in cytosol. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

521 residues, UniProt reviewed canonical sequence.

>A2RU30|TESPA1
     1  MEASVLSPTS WEKRRAWLRQ SRNWQTQVLE EEAAAALQDV PDPEPSSLDD VFQEGNPINK
    61  IEDWLQDCGY SEEGFSEEAG QFIYNGFCSH GTSFEDDLTL GAEATLLAAN GKLFSRSFLE
   121  TARPCQLLDL GCSLASSSMT GGTNKTSSSI SEILDKVQED AEDVLFSLGF GQEDHKDTSR
   181  IPARFFTTPS QAKGIDFQLF LKSQVRRIEM EDPCLMLASR FKQVQTLAVT ADAFFCLYSY
   241  VSKTPVQKFT PSHMFWNCNH PTDVPSIRIL SREPEPQSPR DRLRKAISKM CLYTCPRDRP
   301  PPPHNTPKRN SLDQVVLEVM DKVKEEKQFL QQDSDLGQFS QEDPVPPAEG KKLPTSPYPC
   361  VFCCEEETQQ RMSTVLAPSQ TLDSNPKVPC CTHSLPIEDP QWSTDPAQIR RELCSLPATN
   421  TETHPAKDET FWKRKSRARK SLFQKNLMGR KVKSLDLSIT QQKWKQSVDR PELRRSLSQQ
   481  PQDTFDLEEV QSNSEEEQSQ SRWPSRPRHP HHHQTFAGKD S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TESPA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
80 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 80 nTPM
  • thymus: 70 nTPM
  • basal ganglia: 35 nTPM
  • tonsil: 34 nTPM
  • lymph node: 34 nTPM
  • bone marrow: 14 nTPM

Single-cell type

  • hematopoietic stem cells: 246 nCPM
  • mast cells: 207 nCPM
  • megakaryocyte-erythroid progenitors: 169 nCPM
  • megakaryocyte progenitors: 118 nCPM
  • innate lymphoid cells: 92 nCPM
  • t-cells: 85 nCPM

Immune cell

  • naive CD4 T-cell: 177 nTPM
  • memory CD4 T-cell: 127 nTPM
  • naive CD8 T-cell: 99 nTPM
  • T-reg: 93 nTPM
  • total PBMC: 65 nTPM
  • memory CD8 T-cell: 58 nTPM

Brain region

  • cerebral cortex: 118 nTPM
  • white matter: 73 nTPM
  • basal ganglia: 60 nTPM
  • thalamus: 15 nTPM
  • hippocampal formation: 14 nTPM
  • amygdala: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0
gnomAD missense Z
0.73
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TESPA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TESPA1 as an antibody target. Whether an autoantibody or antibody against TESPA1 could matter depends on whether native TESPA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TESPA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TESPA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TESPA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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