Seroatlas · Human Serome Atlas

MRM1

rRNA methyltransferase 1, mitochondrial

Also known as: FLJ22578, MRM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IN84
Gene: MRM1
Ensembl: ENSG00000278619
Chromosome: 17
Canonical length: 353 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Enables rRNA (guanosine-2'-O-)-methyltransferase activity. Involved in rRNA processing. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

353 residues, UniProt reviewed canonical sequence.

>Q6IN84|MRM1
     1  MALLSTVRGA TWGRLVTRHF SHAARHGERP GGEELSRLLL DDLVPTSRLE LLFGMTPCLL
    61  ALQAARRSVA RLLLQAGKAG LQGKRAELLR MAEARDIPVL RPRRQKLDTM CRYQVHQGVC
   121  MEVSPLRPRP WREAGEASPG DDPQQLWLVL DGIQDPRNFG AVLRSAHFLG VDKVITSRRN
   181  SCPLTPVVSK SSAGAMEVMD VFSTDDLTGF LQTKAQQGWL VAGTVGCPST EDPQSSEIPI
   241  MSCLEFLWER PTLLVLGNEG SGLSQEVQAS CQLLLTILPR RQLPPGLESL NVSVAAGILL
   301  HSICSQRKGF PTEGERRQLL QDPQEPSARS EGLSMAQHPG LSSGPEKERQ NEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 7.7 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 7.7 nTPM
heart muscle: 7.1 nTPM
liver: 7.1 nTPM
pancreas: 6 nTPM
adrenal gland: 5.7 nTPM
colon: 5.7 nTPM

Single-cell type

proximal tubule cells: 6.9 nCPM
brain inhibitory neurons: 6 nCPM
distal convoluted tubule cells: 5.5 nCPM
enteric stem cells: 5.5 nCPM
enteric transient amplifying cells: 5.4 nCPM
microglia: 5.3 nCPM

Immune cell

NK-cell: 6 nTPM
MAIT T-cell: 5.3 nTPM
memory B-cell: 4.4 nTPM
naive B-cell: 3.9 nTPM
naive CD8 T-cell: 3.8 nTPM
naive CD4 T-cell: 3.5 nTPM

Brain region

basal ganglia: 5.2 nTPM
white matter: 5.2 nTPM
thalamus: 5 nTPM
amygdala: 4.5 nTPM
cerebral cortex: 4.5 nTPM
hypothalamus: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

tRNA/rRNA methyltransferase, SpoU type
RNA 2-O ribose methyltransferase, substrate binding
tRNA (guanine-N1-)-methyltransferase, N-terminal
Alpha/beta knot methyltransferases
Ribosomal protein eL30-like superfamily
SpoU rRNA Methylase family
RNA methyltransferase TrmH
rRNA methyltransferase 1, mitochondrial
rRNA methyltransferase 1, methyltransferase domain
RNA 2'-O ribose methyltransferase substrate binding

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRM1 as an antibody target. Whether an autoantibody or antibody against MRM1 could matter depends on whether native MRM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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