Seroatlas · Human Serome Atlas

CEP44

Centrosomal protein of 44 kDa

Also known as: CEP44_HUMAN, KIAA1712

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0F1
Gene: CEP44
Ensembl: ENSG00000164118
Chromosome: 4
Canonical length: 390 aa
Protein class: Predicted intracellular proteins
Subcellular location: Basal body,Cytosol

OverviewNCBI Gene

Enables microtubule binding activity. Involved in centriole replication and centriole-centriole cohesion. Located in cytosol and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

390 residues, UniProt reviewed canonical sequence.

>Q9C0F1|CEP44
     1  MATGDLKRSL RNLEQVLRLL NYPEEVDCVG LIKGDPAASL PIISYSFTSY SPYVTELIME
    61  SNVELIAKND LRFIDAVYKL LRDQFNYKPI LTKKQFIQCG FAEWKIQIVC DILNCVMKKH
   121  KELSSLQKIP SQQRKKISSG KSEPPLGNEK ISAEAVGVDI SGRFMTSGKK KAVVIRHLYN
   181  EDNVDISEDT LSPITDVNEA VDVSDLNATE IKMPEVKVPE IKAEQQDVNV NPEITALQTM
   241  LAECQENLKK LTSIEKRLDC LEQKMKGKVM VDENTWTNLL SRVTLLETEM LLSKKNDEFI
   301  EFNEVSEDYA SCSDMDLLNP HRKSEVERPA SIPLSSGYST ASSDSTPRAS TVNYCGLNEI
   361  SEETTIQKME RMKKMFEETA ELLKCPNHYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
skin: 12 nTPM
retina: 12 nTPM
placenta: 11 nTPM
bone marrow: 10 nTPM
thymus: 10 nTPM

Single-cell type

platelets: 95 nCPM
neutrophil progenitors: 95 nCPM
monocyte progenitors: 89 nCPM
corticotrophs: 64 nCPM
lactotrophs: 60 nCPM
respiratory ciliated cells: 60 nCPM

Immune cell

T-reg: 8.7 nTPM
basophil: 5.9 nTPM
memory B-cell: 5.6 nTPM
naive B-cell: 5.6 nTPM
naive CD4 T-cell: 5.3 nTPM
non-classical monocyte: 4.6 nTPM

Brain region

white matter: 32 nTPM
cerebellum: 29 nTPM
pons: 24 nTPM
basal ganglia: 22 nTPM
hippocampal formation: 22 nTPM
choroid plexus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: 0.49
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Centrosomal CEP44 domain
Centrosomal protein of 44kDa
Centrosomal spindle body, CEP44

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP44 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP44 as an antibody target. Whether an autoantibody or antibody against CEP44 could matter depends on whether native CEP44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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