Seroatlas · Human Serome Atlas

ZMYM3

Zinc finger MYM-type protein 3

Also known as: DXS6673E, KIAA0385, MYM, ZMYM3_HUMAN, ZNF198L2, ZNF261

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14202
Gene: ZMYM3
Ensembl: ENSG00000147130
Chromosome: X
Canonical length: 1370 aa
Protein class: Disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene is located on the X chromosome and is subject to X inactivation. It is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked cognitive disability. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

1370 residues, UniProt reviewed canonical sequence.

>Q14202|ZMYM3
     1  MDPSDFPSPF DPLTLPEKPL AGDLPVDMEF GEDLLESQTA PTRGWAPPGP SPSSGALDLL
    61  DTPAGLEKDP GVLDGATELL GLGGLLYKAP SPPEVDHGPE GTLAWDAGDQ TLEPGPGGQT
   121  PEVVPPDPGA GANSCSPEGL LEPLAPDSPI TLQSPHIEEE ETTSIATARR GSPGQEEELP
   181  QGQPQSPNAP PSPSVGETLG DGINSSQTKP GGSSPPAHPS LPGDGLTAKA SEKPPERKRS
   241  ERVRRAEPPK PEVVDSTESI PVSDEDSDAM VDDPNDEDFV PFRPRRSPRM SLRSSVSQRA
   301  GRSAVGTKMT CAHCRTPLQK GQTAYQRKGL PQLFCSSSCL TTFSKKPSGK KTCTFCKKEI
   361  WNTKDSVVAQ TGSGGSFHEF CTSVCLSLYE AQQQRPIPQS GDPADATRCS ICQKTGEVLH
   421  EVSNGSVVHR LCSDSCFSKF RANKGLKTNC CDQCGAYIYT KTGSPGPELL FHEGQQKRFC
   481  NTTCLGAYKK KNTRVYPCVW CKTLCKNFEM LSHVDRNGKT SLFCSLCCTT SYKVKQAGLT
   541  GPPRPCSFCR RSLSDPCYYN KVDRTVYQFC SPSCWTKFQR TSPEGGIHLS CHYCHSLFSG
   601  KPEVLDWQDQ VFQFCCRDCC EDFKRLRGVV SQCEHCRQEK LLHEKLRFSG VEKSFCSEGC
   661  VLLYKQDFTK KLGLCCITCT YCSQTCQRGV TEQLDGSTWD FCSEDCKSKY LLWYCKAARC
   721  HACKRQGKLL ETIHWRGQIR HFCNQQCLLR FYSQQNQPNL DTQSGPESLL NSQSPESKPQ
   781  TPSQTKVENS NTVRTPEENG NLGKIPVKTR SAPTAPTPPP PPPPATPRKN KAAMCKPLMQ
   841  NRGVSCKVEM KSKGSQTEEW KPQVIVLPIP VPIFVPVPMH LYCQKVPVPF SMPIPVPVPM
   901  FLPTTLESTD KIVETIEELK VKIPSNPLEA DILAMAEMIA EAEELDKASS DLCDLVSNQS
   961  AEGLLEDCDL FGPARDDVLA MAVKMANVLD EPGQDLEADF PKNPLDINPS VDFLFDCGLV
  1021  GPEDVSTEQD LPRTMRKGQK RLVLSESCSR DSMSSQPSCT GLNYSYGVNA WKCWVQSKYA
  1081  NGETSKGDEL RFGPKPMRIK EDILACSAAE LNYGLAQFVR EITRPNGERY EPDSIYYLCL
  1141  GIQQYLLENN RMVNIFTDLY YLTFVQELNK SLSTWQPTLL PNNTVFSRVE EEHLWECKQL
  1201  GVYSPFVLLN TLMFFNTKFF GLQTAEEHMQ LSFTNVVRQS RKCTTPRGTT KVVSIRYYAP
  1261  VRQRKGRDTG PGKRKREDEA PILEQRENRM NPLRCPVKFY EFYLSKCPES LRTRNDVFYL
  1321  QPERSCIAES PLWYSVIPMD RSMLESMLNR ILAVREIYEE LGRPGEEDLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMYM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

ovary: 36 nTPM
adrenal gland: 27 nTPM
testis: 20 nTPM
cerebellum: 19 nTPM
fallopian tube: 19 nTPM
cerebral cortex: 18 nTPM

Single-cell type

sertoli cells: 101 nCPM
ependymal cells: 44 nCPM
granulosa cells: 41 nCPM
adrenal cortex cells: 37 nCPM
leydig cells: 33 nCPM
brain inhibitory neurons: 30 nCPM

Immune cell

plasmacytoid DC: 10 nTPM
memory B-cell: 7.1 nTPM
naive B-cell: 6.6 nTPM
basophil: 6.2 nTPM
classical monocyte: 5.2 nTPM
myeloid DC: 4.9 nTPM

Brain region

hypothalamus: 54 nTPM
basal ganglia: 40 nTPM
cerebral cortex: 37 nTPM
hippocampal formation: 36 nTPM
amygdala: 34 nTPM
midbrain: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZMYM3.

Disease | AllUniProt

Conditions ZMYM3 is implicated in, by any mechanism.

Intellectual developmental disorder, X-linked 112 (XLID112) MIM:301111

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 222 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual developmental disorder, X-linked 112
Global developmental delay
Abnormal facial shape
Hyporeflexia
Neonatal hypotonia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.11
gnomAD pLI: 1
gnomAD missense Z: 4.31
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMYM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMYM3 as an antibody target. Whether an autoantibody or antibody against ZMYM3 could matter depends on whether native ZMYM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMYM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMYM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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