Seroatlas · Human Serome Atlas

SHC1

SHC-transforming protein 1

Also known as: p66, SHC, SHC1_HUMAN, ShcA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P29353
Gene: SHC1
Ensembl: ENSG00000160691
Chromosome: 1
Canonical length: 583 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

583 residues, UniProt reviewed canonical sequence.

>P29353|SHC1
     1  MDLLPPKPKY NPLRNESLSS LEEGASGSTP PEELPSPSAS SLGPILPPLP GDDSPTTLCS
    61  FFPRMSNLRL ANPAGGRPGS KGEPGRAADD GEGIVGAAMP DSGPLPLLQD MNKLSGGGGR
   121  RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD
   181  FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS
   241  LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV
   301  ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL
   361  GGVVDMRLRE GAAPGAARPT APNAQTPSHL GATLPVGQPV GGDPEVRKQM PPPPPCPGRE
   421  LFDDPSYVNV QNLDKARQAV GGAGPPNPAI NGSAPRDLFD MKPFEDALRV PPPPQSVSMA
   481  EQLRGEPWFH GKLSRREAEA LLQLNGDFLV RESTTTPGQY VLTGLQSGQP KHLLLVDPEG
   541  VVRTKDHRFE SVSHLISYHM DNHLPIISAG SELCLQQPVE RKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 138 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 138 nTPM
breast: 123 nTPM
pituitary gland: 113 nTPM
blood vessel: 104 nTPM
smooth muscle: 100 nTPM
lung: 100 nTPM

Single-cell type

epicardial cells: 21 nCPM
lymphatic endothelial cells: 20 nCPM
enterocytes: 19 nCPM
adipocytes: 18 nCPM
salivary myoepithelial cells: 12 nCPM
medullary thymic epithelial cells: 9.6 nCPM

Immune cell

eosinophil: 58 nTPM
non-classical monocyte: 48 nTPM
intermediate monocyte: 48 nTPM
total PBMC: 39 nTPM
gdT-cell: 39 nTPM
MAIT T-cell: 39 nTPM

Brain region

thalamus: 63 nTPM
pons: 56 nTPM
medulla oblongata: 55 nTPM
cerebral cortex: 54 nTPM
hypothalamus: 48 nTPM
spinal cord: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
gnomAD missense Z: 1.33
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SHC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHC1 as an antibody target. Whether an autoantibody or antibody against SHC1 could matter depends on whether native SHC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHC1 is annotated at the cell surface, where native SHC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SHC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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