CDS1

Protein identityUniProt · HPA

UniProt accession

Q92903

Gene

CDS1

Ensembl

ENSG00000163624

Chromosome

4

Canonical length

461 aa

Protein class

Enzymes, Metabolic proteins, Predicted membrane proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>Q92903|CDS1
     1  MLELRHRGSC PGPREAVSPP HREGEAAGGD HETESTSDKE TDIDDRYGDL DSRTDSDIPE
    61  IPPSSDRTPE ILKKALSGLS SRWKNWWIRG ILTLTMISLF FLIIYMGSFM LMLLVLGIQV
   121  KCFHEIITIG YRVYHSYDLP WFRTLSWYFL LCVNYFFYGE TVADYFATFV QREEQLQFLI
   181  RYHRFISFAL YLAGFCMFVL SLVKKHYRLQ FYMFAWTHVT LLITVTQSHL VIQNLFEGMI
   241  WFLVPISSVI CNDITAYLFG FFFGRTPLIK LSPKKTWEGF IGGFFSTVVF GFIAAYVLSK
   301  YQYFVCPVEY RSDVNSFVTE CEPSELFQLQ TYSLPPFLKA VLRQERVSLY PFQIHSIALS
   361  TFASLIGPFG GFFASGFKRA FKIKDFANTI PGHGGIMDRF DCQYLMATFV HVYITSFIRG
   421  PNPSKVLQQL LVLQPEQQLN IYKTLKTHLI EKGILQPTLK V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

6

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

38 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.65

gnomAD pLI

0

gnomAD missense Z

1.48

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• CDP-diacylglycerol biosynthetic process
• lipid droplet formation
• phosphatidylinositol biosynthetic process
• phototransduction
• positive regulation of fat cell differentiation
• signal transduction

Molecular functions

• diacylglycerol cholinephosphotransferase activity
• phosphatidate cytidylyltransferase activity

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane
• membrane

Protein domainsUniProt · Pfam · InterPro

• Phosphatidate cytidylyltransferase
• Phosphatidate cytidylyltransferase, eukaryota
• Cytidylyltransferase family

KeywordsUniProt

• Endoplasmic reticulum
• Lipid biosynthesis
• Lipid metabolism
• Magnesium
• Membrane
• Methylation
• Nucleotidyltransferase
• Phospholipid biosynthesis
• Phospholipid metabolism
• Phosphoprotein
• Transferase
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of CDS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FOS
• CDS2