Seroatlas · Human Serome Atlas

PI4K2A

Phosphatidylinositol 4-kinase type 2-alpha

Also known as: DKFZP761G1923, P4K2A_HUMAN, PI4KII, PIK42A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BTU6
Gene
PI4K2A
Ensembl
ENSG00000155252
Chromosome
10
Canonical length
479 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>Q9BTU6|PI4K2A
     1  MDETSPLVSP ERAQPPDYTF PSGSGAHFPQ VPGGAVRVAA AAGSGPSPPG SPGHDRERQP
    61  LLDRARGAAA QGQTQTVAAQ AQALAAQAAA AAHAAQAHRE RNEFPEDPEF EAVVRQAELA
   121  IERCIFPERI YQGSSGSYFV KDPQGRIIAV FKPKNEEPYG HLNPKWTKWL QKLCCPCCFG
   181  RDCLVLNQGY LSEAGASLVD QKLELNIVPR TKVVYLASET FNYSAIDRVK SRGKRLALEK
   241  VPKVGQRFNR IGLPPKVGSF QLFVEGYKDA DYWLRRFEAE PLPENTNRQL LLQFERLVVL
   301  DYIIRNTDRG NDNWLIKYDC PMDSSSSRDT DWVVVKEPVI KVAAIDNGLA FPLKHPDSWR
   361  AYPFYWAWLP QAKVPFSQEI KDLILPKISD PNFVKDLEED LYELFKKDPG FDRGQFHKQI
   421  AVMRGQILNL TQALKDNKSP LHLVQMPPVI VETARSHQRS SSESYTQSFQ SRKPFFSWW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PI4K2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 25 nTPM
  • bone marrow: 23 nTPM
  • cerebral cortex: 20 nTPM
  • esophagus: 20 nTPM
  • choroid plexus: 17 nTPM
  • placenta: 17 nTPM

Single-cell type

  • esophageal apical cells: 102 nCPM
  • hofbauer cells: 57 nCPM
  • ocular epithelial cells: 33 nCPM
  • epicardial cells: 32 nCPM
  • syncytiotrophoblasts: 31 nCPM
  • microglia: 28 nCPM

Immune cell

  • memory B-cell: 1.4 nTPM
  • gdT-cell: 1.3 nTPM
  • myeloid DC: 1.3 nTPM
  • classical monocyte: 1.2 nTPM
  • T-reg: 1.2 nTPM
  • memory CD8 T-cell: 1.1 nTPM

Brain region

  • pons: 41 nTPM
  • medulla oblongata: 36 nTPM
  • midbrain: 35 nTPM
  • cerebral cortex: 33 nTPM
  • hypothalamus: 32 nTPM
  • thalamus: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PI4K2A.

Disease | AllUniProt

Conditions PI4K2A is implicated in, by any mechanism.

  • Neurodevelopmental disorder with hyperkinetic movements, seizures, and structural brain abnormalities (NEDMSB) MIM:620732

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 53 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodevelopmental disorder with hyperkinetic movements, seizures, and structural brain abnormalities

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.8
gnomAD missense Z
2.89
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PI4K2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PI4K2A as an antibody target. Whether an autoantibody or antibody against PI4K2A could matter depends on whether native PI4K2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PI4K2A is annotated at the cell surface, where native PI4K2A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PI4K2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PI4K2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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