JUND
Transcription factor JunD
Also known as: AP-1, JUND_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P17535
- Gene
- JUND
- Ensembl
- ENSG00000130522
- Chromosome
- 19
- Canonical length
- 347 aa
- Protein class
- Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]
Canonical amino-acid sequenceUniProt
347 residues, UniProt reviewed canonical sequence.
>P17535|JUND
1 METPFYGDEA LSGLGGGASG SGGSFASPGR LFPGAPPTAA AGSMMKKDAL TLSLSEQVAA
61 ALKPAAAPPP TPLRADGAPS AAPPDGLLAS PDLGLLKLAS PELERLIIQS NGLVTTTPTS
121 SQFLYPKVAA SEEQEFAEGF VKALEDLHKQ NQLGAGAAAA AAAAAAGGPS GTATGSAPPG
181 ELAPAAAAPE APVYANLSSY AGGAGGAGGA ATVAFAAEPV PFPPPPPPGA LGPPRLAALK
241 DEPQTVPDVP SFGESPPLSP IDMDTQERIK AERKRLRNRI AASKCRKRKL ERISRLEEKV
301 KTLKSQNTEL ASTASLLREQ VAQLKQKVLS HVNSGCQLLP QHQVPAYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against JUND can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.66
- Highest tissue expression
- 404 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 404 nTPM
- ovary: 398 nTPM
- blood vessel: 280 nTPM
- fallopian tube: 279 nTPM
- adipose tissue: 275 nTPM
- skin: 275 nTPM
Single-cell type
- innate lymphoid cells: 2,149 nCPM
- mast cells: 1,959 nCPM
- fallopian secretory cells: 1,850 nCPM
- pancreatic duct cells: 1,829 nCPM
- breast hormone-responsive cells: 1,733 nCPM
- endometrial glandular cells: 1,644 nCPM
Immune cell
- neutrophil: 20 nTPM
- plasmacytoid DC: 11 nTPM
- basophil: 11 nTPM
- naive B-cell: 8.8 nTPM
- memory B-cell: 8.4 nTPM
- non-classical monocyte: 8.4 nTPM
Brain region
- white matter: 452 nTPM
- medulla oblongata: 451 nTPM
- midbrain: 357 nTPM
- cerebral cortex: 335 nTPM
- hypothalamus: 305 nTPM
- amygdala: 299 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.75
- gnomAD pLI
- 0.7
- gnomAD missense Z
- 1.4
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cellular response to calcium ion
- cellular response to fatty acid
- cellular response to hypoxia
- circadian rhythm
- negative regulation of transcription by RNA polymerase II
- osteoblast development
- positive regulation of macrophage activation
- positive regulation of osteoblast differentiation
- positive regulation of peroxisome proliferator activated receptor signaling pathway
- positive regulation of transcription by RNA polymerase II
- regulation of cell cycle
- regulation of cell population proliferation
- regulation of transcription by RNA polymerase II
- response to forskolin
- response to light stimulus
- response to lipopolysaccharide
- response to mechanical stimulus
- response to peptide hormone
- response to steroid hormone
- transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- enzyme binding
- nuclear receptor binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- transcription cis-regulatory region binding
- transcription coactivator activity
- transcription coregulator binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of JUND in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads JUND as an antibody target. Whether an autoantibody or antibody against JUND could matter depends on whether native JUND is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
JUND is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label JUND as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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