Seroatlas · Human Serome Atlas

JUNB

Transcription factor JunB

Also known as: JUNB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P17275
Gene
JUNB
Ensembl
ENSG00000171223
Chromosome
19
Canonical length
347 aa
Protein class
Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription factor AP-1 complex. Implicated in head and neck squamous cell carcinoma and melanoma. Biomarker of gastrointestinal system cancer (multiple); lung non-small cell carcinoma; and lymphoma (multiple). [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>P17275|JUNB
     1  MCTKMEQPFY HDDSYTATGY GRAPGGLSLH DYKLLKPSLA VNLADPYRSL KAPGARGPGP
    61  EGGGGGSYFS GQGSDTGASL KLASSELERL IVPNSNGVIT TTPTPPGQYF YPRGGGSGGG
   121  AGGAGGGVTE EQEGFADGFV KALDDLHKMN HVTPPNVSLG ATGGPPAGPG GVYAGPEPPP
   181  VYTNLSSYSP ASASSGGAGA AVGTGSSYPT TTISYLPHAP PFAGGHPAQL GLGRGASTFK
   241  EEPQTVPEAR SRDATPPVSP INMEDQERIK VERKRLRNRL AATKCRKRKL ERIARLEDKV
   301  KTLKAENAGL SSTAGLLREQ VAQLKQKVMT HVSNGCQLLL GVKGHAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JUNB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
1,054 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 1,054 nTPM
  • adipose tissue: 679 nTPM
  • ovary: 605 nTPM
  • skin: 574 nTPM
  • fallopian tube: 564 nTPM
  • esophagus: 433 nTPM

Single-cell type

  • decidual stromal cells: 5,567 nCPM
  • ovarian stromal cells: 5,401 nCPM
  • esophageal apical cells: 4,765 nCPM
  • neutrophils: 3,352 nCPM
  • vascular smooth muscle cells: 3,221 nCPM
  • smooth muscle cells: 3,170 nCPM

Immune cell

  • neutrophil: 682 nTPM
  • intermediate monocyte: 183 nTPM
  • non-classical monocyte: 178 nTPM
  • eosinophil: 132 nTPM
  • classical monocyte: 132 nTPM
  • total PBMC: 124 nTPM

Brain region

  • cerebellum: 197 nTPM
  • medulla oblongata: 191 nTPM
  • hypothalamus: 162 nTPM
  • cerebral cortex: 148 nTPM
  • spinal cord: 125 nTPM
  • white matter: 88 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about JUNB.

Disease | ImmuneIEDB

Conditions an epitope on JUNB was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.86
gnomAD missense Z
2.17
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JUNB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JUNB as an antibody target. Whether an autoantibody or antibody against JUNB could matter depends on whether native JUNB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JUNB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JUNB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/JUNB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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