Potentiating neddylation domain

Definition

This domain is found in the eukaryotic family defective in cullin neddylation, which includes DCN1 and DCN1-like proteins. Proteins of the DCN family may contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes, which are multi-protein complexes required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome [[cite:PMID:15988528], [cite:PMID:18826954]]. The structure of this domain is composed entirely of α helices [[cite:PMID:17597076], [cite:PMID:18206966]]. It has been referred to as potentiating neddylation domain (PONY) and can be found in association with an N-terminal UBA domain. The PONY domain contains a cullin-binding surface within its C-terminal region and is sufficient to promote neddylation [[cite:PMID:18206966], [cite:PMID:23201271]].

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• DCUN1D1
• DCUN1D2
• DCUN1D3
• DCUN1D4
• DCUN1D5