Defective-in-cullin neddylation protein

Definition

The eukaryotic defective in cullin neddylation (DCN) protein family, contributes to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. These multi-protein complexes are required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome [[cite:PMID:15988528], [cite:PMID:23201271], [cite:PMID:26906416]]. Proteins in the DCN family include: Yeast DCN1. Vertebrate DCN1-like protein 1-5. Plant Defective in cullin neddylation protein AAR3 PMID:17905859. DCN family proteins all contain a Potentiating neddylation (PONY) domain ([interpro:IPR005176]), contains a cullin-binding surface within its C-terminal region and is sufficient to promote neddylation [[cite:PMID:18206966], [cite:PMID:23201271]]. The N-terminal region of the protein often contains a UBA-like domain.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• DCUN1D1
• DCUN1D2
• DCUN1D3
• DCUN1D4
• DCUN1D5