Seroatlas · Human Serome Atlas

IL17RB

Interleukin-17 receptor B

Also known as: CRL4, EVI27, I17RB_HUMAN, IL17BR, IL17RH1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRM6
Gene: IL17RB
Ensembl: ENSG00000056736
Chromosome: 3
Canonical length: 502 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles,Plasma membrane
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

502 residues, UniProt reviewed canonical sequence.

>Q9NRM6|IL17RB
     1  MSLVLLSLAA LCRSAVPREP TVQCGSETGP SPEWMLQHDL IPGDLRDLRV EPVTTSVATG
    61  DYSILMNVSW VLRADASIRL LKATKICVTG KSNFQSYSCV RCNYTEAFQT QTRPSGGKWT
   121  FSYIGFPVEL NTVYFIGAHN IPNANMNEDG PSMSVNFTSP GCLDHIMKYK KKCVKAGSLW
   181  DPNITACKKN EETVEVNFTT TPLGNRYMAL IQHSTIIGFS QVFEPHQKKQ TRASVVIPVT
   241  GDSEGATVQL TPYFPTCGSD CIRHKGTVVL CPQTGVPFPL DNNKSKPGGW LPLLLLSLLV
   301  ATWVLVAGIY LMWRHERIKK TSFSTTTLLP PIKVLVVYPS EICFHHTICY FTEFLQNHCR
   361  SEVILEKWQK KKIAEMGPVQ WLATQKKAAD KVVFLLSNDV NSVCDGTCGK SEGSPSENSQ
   421  DLFPLAFNLF CSDLRSQIHL HKYVVVYFRE IDTKDDYNAL SVCPKYHLMK DATAFCAELL
   481  HVKQQVSAGK RSQACHDGCC SL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL17RB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

kidney: 56 nTPM
liver: 31 nTPM
cerebral cortex: 17 nTPM
basal ganglia: 17 nTPM
cervix: 17 nTPM
amygdala: 17 nTPM

Single-cell type

tuft cells: 657 nCPM
pancreatic duct cells: 72 nCPM
bergmann glia: 70 nCPM
paneth cells: 66 nCPM
proximal tubule cells: 66 nCPM
oligodendrocyte progenitor cells: 59 nCPM

Immune cell

basophil: 1.3 nTPM
T-reg: 0.9 nTPM
memory CD4 T-cell: 0.6 nTPM
plasmacytoid DC: 0.3 nTPM
classical monocyte: 0.2 nTPM
gdT-cell: 0.2 nTPM

Brain region

thalamus: 24 nTPM
white matter: 24 nTPM
cerebellum: 23 nTPM
basal ganglia: 21 nTPM
cerebral cortex: 19 nTPM
amygdala: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: -0.26
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL17RB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL17RB as an antibody target. Whether an autoantibody or antibody against IL17RB could matter depends on whether native IL17RB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL17RB is annotated at the cell surface, where native IL17RB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL17RB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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