Seroatlas · Human Serome Atlas

MITD1

MIT domain-containing protein 1

Also known as: LOC129531, MITD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WV92
Gene
MITD1
Ensembl
ENSG00000158411
Chromosome
2
Canonical length
249 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as a homodimer, with the N-termini binding to a subset of ESCRT-III subunits and the C-termini binding to membranes. The encoded protein regulates ESCRT-III activity and is required for proper cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

249 residues, UniProt reviewed canonical sequence.

>Q8WV92|MITD1
     1  MAKSGLRQDP QSTAAATVLK RAVELDSESR YPQALVCYQE GIDLLLQVLK GTKDNTKRCN
    61  LREKISKYMD RAENIKKYLD QEKEDGKYHK QIKIEENATG FSYESLFREY LNETVTEVWI
   121  EDPYIRHTHQ LYNFLRFCEM LIKRPCKVKT IHLLTSLDEG IEQVQQSRGL QEIEESLRSH
   181  GVLLEVQYSS SIHDREIRFN NGWMIKIGRG LDYFKKPQSR FSLGYCDFDL RPCHETTVDI
   241  FHKKHTKNI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MITD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 34 nTPM
  • tonsil: 27 nTPM
  • thymus: 25 nTPM
  • appendix: 24 nTPM
  • spleen: 21 nTPM
  • retina: 21 nTPM

Single-cell type

  • rod photoreceptor cells: 88 nCPM
  • hofbauer cells: 70 nCPM
  • pituitary stem cells: 66 nCPM
  • esophageal basal cells: 61 nCPM
  • b-cells: 59 nCPM
  • cytotrophoblasts: 59 nCPM

Immune cell

  • memory B-cell: 31 nTPM
  • plasmacytoid DC: 30 nTPM
  • naive B-cell: 29 nTPM
  • neutrophil: 28 nTPM
  • NK-cell: 26 nTPM
  • memory CD4 T-cell: 25 nTPM

Brain region

  • white matter: 9.3 nTPM
  • medulla oblongata: 8.3 nTPM
  • hypothalamus: 8 nTPM
  • basal ganglia: 7.8 nTPM
  • pons: 7.7 nTPM
  • cerebral cortex: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
0.57
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MITD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MITD1 as an antibody target. Whether an autoantibody or antibody against MITD1 could matter depends on whether native MITD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MITD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MITD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MITD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...