Seroatlas · Human Serome Atlas

VTA1

Vacuolar protein sorting-associated protein VTA1 homolog

Also known as: C6orf55, HSPC228, My012, VTA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NP79
Gene
VTA1
Ensembl
ENSG00000009844
Chromosome
6
Canonical length
307 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

C6ORF55 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes (Ward et al., 2005 [PubMed 15644320]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q9NP79|VTA1
     1  MAALAPLPPL PAQFKSIQHH LRTAQEHDKR DPVVAYYCRL YAMQTGMKID SKTPECRKFL
    61  SKLMDQLEAL KKQLGDNEAI TQEIVGCAHL ENYALKMFLY ADNEDRAGRF HKNMIKSFYT
   121  ASLLIDVITV FGELTDENVK HRKYARWKAT YIHNCLKNGE TPQAGPVGIE EDNDIEENED
   181  AGAASLPTQP TQPSSSSTYD PSNMPSGNYT GIQIPPGAHA PANTPAEVPH STGVASNTIQ
   241  PTPQTIPAID PALFNTISQG DVRLTPEDFA RAQKYCKYAG SALQYEDVST AVQNLQKALK
   301  LLTTGRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VTA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 54 nTPM
  • skeletal muscle: 52 nTPM
  • liver: 42 nTPM
  • thymus: 42 nTPM
  • rectum: 38 nTPM
  • esophagus: 37 nTPM

Single-cell type

  • esophageal apical cells: 113 nCPM
  • neutrophil progenitors: 101 nCPM
  • esophageal suprabasal cells: 75 nCPM
  • megakaryocytes: 74 nCPM
  • extravillous trophoblasts: 71 nCPM
  • adrenal cortex cells: 68 nCPM

Immune cell

  • basophil: 223 nTPM
  • eosinophil: 152 nTPM
  • total PBMC: 121 nTPM
  • non-classical monocyte: 121 nTPM
  • intermediate monocyte: 115 nTPM
  • NK-cell: 98 nTPM

Brain region

  • white matter: 38 nTPM
  • spinal cord: 37 nTPM
  • cerebellum: 35 nTPM
  • cerebral cortex: 34 nTPM
  • hypothalamus: 33 nTPM
  • hippocampal formation: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VTA1.

Disease | ImmuneIEDB

Conditions an epitope on VTA1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.9
gnomAD pLI
0
gnomAD missense Z
-0.31
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Vta1/Callose synthase, N-terminal domain superfamily
  • Vta1/callose synthase, N-terminal
  • Vta1, C-terminal
  • Vacuolar protein sorting-associated protein Vta1-like
  • Vta1 like
  • Vta1 C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VTA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VTA1 as an antibody target. Whether an autoantibody or antibody against VTA1 could matter depends on whether native VTA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VTA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VTA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VTA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...