Seroatlas · Human Serome Atlas

USP37

Ubiquitin carboxyl-terminal hydrolase 37

Also known as: KIAA1594, UBP37_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86T82
Gene: USP37
Ensembl: ENSG00000135913
Chromosome: 2
Canonical length: 979 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; and protein kinase binding activity. Involved in G1/S transition of mitotic cell cycle; protein deubiquitination; and regulation of DNA replication. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

979 residues, UniProt reviewed canonical sequence.

>Q86T82|USP37
     1  MSPLKIHGPI RIRSMQTGIT KWKEGSFEIV EKENKVSLVV HYNTGGIPRI FQLSHNIKNV
    61  VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD AVHQNRLPAA MKPSQGSGSF
   121  GAILGSRTSQ KETSRQLSYS DNQASAKRGS LETKDDIPFR KVLGNPGRGS IKTVAGSGIA
   181  RTIPSLTSTS TPLRSGLLEN RTEKRKRMIS TGSELNEDYP KENDSSSNNK AMTDPSRKYL
   241  TSSREKQLSL KQSEENRTSG LLPLQSSSFY GSRAGSKEHS SGGTNLDRTN VSSQTPSAKR
   301  SLGFLPQPVP LSVKKLRCNQ DYTGWNKPRV PLSSHQQQQL QGFSNLGNTC YMNAILQSLF
   361  SLQSFANDLL KQGIPWKKIP LNALIRRFAH LLVKKDICNS ETKKDLLKKV KNAISATAER
   421  FSGYMQNDAH EFLSQCLDQL KEDMEKLNKT WKTEPVSGEE NSPDISATRA YTCPVITNLE
   481  FEVQHSIICK ACGEIIPKRE QFNDLSIDLP RRKKPLPPRS IQDSLDLFFR AEELEYSCEK
   541  CGGKCALVRH KFNRLPRVLI LHLKRYSFNV ALSLNNKIGQ QVIIPRYLTL SSHCTENTKP
   601  PFTLGWSAHM AISRPLKASQ MVNSCITSPS TPSKKFTFKS KSSLALCLDS DSEDELKRSV
   661  ALSQRLCEML GNEQQQEDLE KDSKLCPIEP DKSELENSGF DRMSEEELLA AVLEISKRDA
   721  SPSLSHEDDD KPTSSPDTGF AEDDIQEMPE NPDTMETEKP KTITELDPAS FTEITKDCDE
   781  NKENKTPEGS QGEVDWLQQY DMEREREEQE LQQALAQSLQ EQEAWEQKED DDLKRATELS
   841  LQEFNNSFVD ALGSDEDSGN EDVFDMEYTE AEAEELKRNA ETGNLPHSYR LISVVSHIGS
   901  TSSSGHYISD VYDIKKQAWF TYNDLEVSKI QEAAVQSDRD RSGYIFFYMH KEIFDELLET
   961  EKNSQSLSTE VGKTTRQAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USP37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
bone marrow: 11 nTPM
retina: 8.3 nTPM
epididymis: 7 nTPM
thymus: 5.9 nTPM
lymph node: 5.5 nTPM

Single-cell type

sertoli cells: 278 nCPM
late spermatids: 229 nCPM
early spermatids: 188 nCPM
vascular smooth muscle cells: 153 nCPM
somatotrophs: 153 nCPM
early primary spermatocytes: 149 nCPM

Immune cell

basophil: 4.1 nTPM
naive CD4 T-cell: 4 nTPM
eosinophil: 3.8 nTPM
T-reg: 3.6 nTPM
MAIT T-cell: 3.2 nTPM
naive B-cell: 3.2 nTPM

Brain region

cerebellum: 35 nTPM
white matter: 34 nTPM
basal ganglia: 27 nTPM
cerebral cortex: 27 nTPM
midbrain: 27 nTPM
medulla oblongata: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 2.46
DepMap mean gene effect: -0.85
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of USP37 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USP37 as an antibody target. Whether an autoantibody or antibody against USP37 could matter depends on whether native USP37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USP37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USP37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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