Seroatlas · Human Serome Atlas

BSG

Basigin

Also known as: BASI_HUMAN, CD147, EMMPRIN, EMPRIN, OK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35613
Gene
BSG
Ensembl
ENSG00000172270
Chromosome
19
Canonical length
385 aa
Protein class
Blood group antigen proteins, CD markers, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles,Mid piece,Principal piece,End piece
Quaternary structure
Homooligomer

OverviewNCBI Gene

The protein encoded by this gene, basigin, is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. Basigin is also a member of the immunoglobulin superfamily, ubiquitously expressed in various tissues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>P35613|BSG
     1  MAAALFVLLG FALLGTHGAS GAAGFVQAPL SQQRWVGGSV ELHCEAVGSP VPEIQWWFEG
    61  QGPNDTCSQL WDGARLDRVH IHATYHQHAA STISIDTLVE EDTGTYECRA SNDPDRNHLT
   121  RAPRVKWVRA QAVVLVLEPG TVFTTVEDLG SKILLTCSLN DSATEVTGHR WLKGGVVLKE
   181  DALPGQKTEF KVDSDDQWGE YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML
   241  VCKSESVPPV TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR
   301  CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK PEDVLDDDDA
   361  GSAPLKSSGQ HQNDKGKNVR QRNSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BSG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
1,787 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 1,787 nTPM
  • choroid plexus: 1,464 nTPM
  • basal ganglia: 621 nTPM
  • cerebral cortex: 575 nTPM
  • kidney: 562 nTPM
  • adrenal gland: 556 nTPM

Single-cell type

  • syncytiotrophoblasts: 1,878 nCPM
  • cytotrophoblasts: 1,736 nCPM
  • colonocytes: 1,507 nCPM
  • decidual stromal cells: 1,468 nCPM
  • extravillous trophoblasts: 1,432 nCPM
  • migrating cytotrophoblasts: 1,316 nCPM

Immune cell

  • neutrophil: 477 nTPM
  • total PBMC: 434 nTPM
  • eosinophil: 350 nTPM
  • classical monocyte: 325 nTPM
  • non-classical monocyte: 286 nTPM
  • intermediate monocyte: 246 nTPM

Brain region

  • choroid plexus: 1,238 nTPM
  • thalamus: 721 nTPM
  • cerebral cortex: 559 nTPM
  • amygdala: 551 nTPM
  • hippocampal formation: 501 nTPM
  • basal ganglia: 470 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0
gnomAD missense Z
-0.14
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BSG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BSG as an antibody target. Whether an autoantibody or antibody against BSG could matter depends on whether native BSG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BSG is annotated at the cell surface, where native BSG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BSG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BSG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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