Seroatlas · Human Serome Atlas

ATP1B2

Sodium/potassium-transporting ATPase subunit beta-2

Also known as: AMOG, AT1B2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P14415
Gene
ATP1B2
Ensembl
ENSG00000129244
Chromosome
17
Canonical length
290 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

290 residues, UniProt reviewed canonical sequence.

>P14415|ATP1B2
     1  MVIQKEKKSC GQVVEEWKEF VWNPRTHQFM GRTGTSWAFI LLFYLVFYGF LTAMFTLTMW
    61  VMLQTVSDHT PKYQDRLATP GLMIRPKTEN LDVIVNVSDT ESWDQHVQKL NKFLEPYNDS
   121  IQAQKNDVCR PGRYYEQPDN GVLNYPKRAC QFNRTQLGNC SGIGDSTHYG YSTGQPCVFI
   181  KMNRVINFYA GANQSMNVTC AGKRDEDAEN LGNFVMFPAN GNIDLMYFPY YGKKFHVNYT
   241  QPLVAVKFLN VTPNVEVNVE CRINAANIAT DDERDKFAGR VAFKLRINKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP1B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
570 nTPM

Expression across tissuesHPA

Tissue

  • retina: 570 nTPM
  • basal ganglia: 290 nTPM
  • cerebellum: 261 nTPM
  • cerebral cortex: 257 nTPM
  • amygdala: 247 nTPM
  • midbrain: 199 nTPM

Single-cell type

  • astrocytes: 353 nCPM
  • bergmann glia: 263 nCPM
  • müller glia: 251 nCPM
  • pituicytes/fscs: 234 nCPM
  • retinal bipolar cells: 223 nCPM
  • retinal pigment epithelial cells: 213 nCPM

Immune cell

  • gdT-cell: 0.3 nTPM
  • basophil: 0.2 nTPM
  • MAIT T-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • neutrophil: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • midbrain: 905 nTPM
  • thalamus: 864 nTPM
  • medulla oblongata: 820 nTPM
  • pons: 675 nTPM
  • cerebral cortex: 662 nTPM
  • cerebellum: 638 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0.07
gnomAD missense Z
0.82
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATP1B2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP1B2 as an antibody target. Whether an autoantibody or antibody against ATP1B2 could matter depends on whether native ATP1B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP1B2 is annotated at the cell surface, where native ATP1B2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ATP1B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ATP1B2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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