Seroatlas · Human Serome Atlas

PPIL2

RING-type E3 ubiquitin-protein ligase PPIL2

Also known as: CYC4, Cyp-60, PPIL2_HUMAN, UBOX7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13356
Gene
PPIL2
Ensembl
ENSG00000100023
Chromosome
22
Canonical length
520 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q13356|PPIL2
     1  MGKRQHQKDK MYITCAEYTH FYGGKKPDLP QTNFRRLPFD HCSLSLQPFV YPVCTPDGIV
    61  FDLLNIVPWL KKYGTNPSNG EKLDGRSLIK LNFSKNSEGK YHCPVLFTVF TNNTHIVAVR
   121  TTGNVYAYEA VEQLNIKAKN FRDLLTDEPF SRQDIITLQD PTNLDKFNVS NFYHVKNNMK
   181  IIDPDEEKAK QDPSYYLKNT NAETRETLQE LYKEFKGDEI LAATMKAPEK KKVDKLNAAH
   241  YSTGKVSASF TSTAMVPETT HEAAAIDEDV LRYQFVKKKG YVRLHTNKGD LNLELHCDLT
   301  PKTCENFIRL CKKHYYDGTI FHRSIRNFVI QGGDPTGTGT GGESYWGKPF KDEFRPNLSH
   361  TGRGILSMAN SGPNSNRSQF FITFRSCAYL DKKHTIFGRV VGGFDVLTAM ENVESDPKTD
   421  RPKEEIRIDA TTVFVDPYEE ADAQIAQERK TQLKVAPETK VKSSQPQAGS QGPQTFRQGV
   481  GKYINPAATK RAAEEEPSTS ATVPMSKKKP SRGFGDFSSW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPIL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 16 nTPM
  • parathyroid gland: 15 nTPM
  • tonsil: 15 nTPM
  • lymph node: 15 nTPM
  • thymus: 15 nTPM
  • skeletal muscle: 14 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 84 nCPM
  • proximal tubule cells: 72 nCPM
  • nk-cells: 63 nCPM
  • esophageal apical cells: 63 nCPM
  • loop of henle epithelial cells: 62 nCPM
  • distal convoluted tubule cells: 59 nCPM

Immune cell

  • non-classical monocyte: 23 nTPM
  • T-reg: 16 nTPM
  • intermediate monocyte: 15 nTPM
  • NK-cell: 14 nTPM
  • myeloid DC: 14 nTPM
  • memory CD8 T-cell: 13 nTPM

Brain region

  • cerebral cortex: 20 nTPM
  • basal ganglia: 17 nTPM
  • hypothalamus: 16 nTPM
  • amygdala: 16 nTPM
  • white matter: 15 nTPM
  • hippocampal formation: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0
gnomAD missense Z
1.64
DepMap mean gene effect
-1.37
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPIL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPIL2 as an antibody target. Whether an autoantibody or antibody against PPIL2 could matter depends on whether native PPIL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPIL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPIL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPIL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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