C19orf25
UPF0449 protein C19orf25
Also known as: CS025_HUMAN, FLJ36666
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UFG5
- Gene
- C19orf25
- Ensembl
- ENSG00000119559
- Chromosome
- 19
- Canonical length
- 118 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Intermediate filaments
OverviewNCBI Gene
No narrative summary is available for C19orf25 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
118 residues, UniProt reviewed canonical sequence.
>Q9UFG5|C19orf25
1 MGSKAKKRVL LPTRPAPPTV EQILEDVRGA PAEDPVFTIL APEDPPVPFR MMEDAEAPGE
61 QLYQQSRAYV AANQRLQQAG NVLRQRCELL QRAGEDLERE VAQMKQAALP AAEAASSGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C19orf25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 43 nTPM
Expression across tissuesHPA
Tissue
- amygdala: 43 nTPM
- cerebral cortex: 42 nTPM
- hippocampal formation: 40 nTPM
- midbrain: 39 nTPM
- spinal cord: 39 nTPM
- basal ganglia: 36 nTPM
Single-cell type
- enterocytes: 96 nCPM
- esophageal apical cells: 85 nCPM
- colonocytes: 73 nCPM
- retinal horizontal cells: 72 nCPM
- syncytiotrophoblasts: 69 nCPM
- müller glia: 59 nCPM
Immune cell
- eosinophil: 59 nTPM
- T-reg: 53 nTPM
- neutrophil: 52 nTPM
- basophil: 51 nTPM
- plasmacytoid DC: 48 nTPM
- naive B-cell: 46 nTPM
Brain region
- white matter: 43 nTPM
- medulla oblongata: 42 nTPM
- thalamus: 40 nTPM
- amygdala: 38 nTPM
- basal ganglia: 38 nTPM
- midbrain: 37 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.7
- gnomAD pLI
- 0.4
- gnomAD missense Z
- -0.22
- DepMap mean gene effect
- -0.22
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Uncharacterised protein family UPF0449
- Uncharacterised protein family UPF0449
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of C19orf25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C19orf25 as an antibody target. Whether an autoantibody or antibody against C19orf25 could matter depends on whether native C19orf25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C19orf25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C19orf25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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