Seroatlas · Human Serome Atlas

ATP5PB

ATP synthase peripheral stalk subunit b, mitochondrial

Also known as: AT5F1_HUMAN, ATP5F1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P24539
Gene
ATP5PB
Ensembl
ENSG00000116459
Chromosome
1
Canonical length
256 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Mitochondria
Quaternary structure
Homooctamer

OverviewNCBI Gene

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

256 residues, UniProt reviewed canonical sequence.

>P24539|ATP5PB
     1  MLSRVVLSAA ATAAPSLKNA AFLGPGVLQA TRTFHTGQPH LVPVPPLPEY GGKVRYGLIP
    61  EEFFQFLYPK TGVTGPYVLG TGLILYALSK EIYVISAETF TALSVLGVMV YGIKKYGPFV
   121  ADFADKLNEQ KLAQLEEAKQ ASIQHIQNAI DTEKSQQALV QKRHYLFDVQ RNNIAMALEV
   181  TYRERLYRVY KEVKNRLDYH ISVQNMMRRK EQEHMINWVE KHVVQSISTQ QEKETIAKCI
   241  ADLKLLAKKA QAQPVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP5PB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
128 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 128 nTPM
  • tongue: 123 nTPM
  • heart muscle: 102 nTPM
  • choroid plexus: 52 nTPM
  • colon: 48 nTPM
  • kidney: 38 nTPM

Single-cell type

  • parietal cells: 900 nCPM
  • esophageal suprabasal cells: 586 nCPM
  • late primary spermatocytes: 584 nCPM
  • esophageal apical cells: 517 nCPM
  • esophageal basal cells: 487 nCPM
  • extravillous trophoblasts: 449 nCPM

Immune cell

  • total PBMC: 46 nTPM
  • naive CD4 T-cell: 17 nTPM
  • myeloid DC: 17 nTPM
  • classical monocyte: 16 nTPM
  • naive B-cell: 15 nTPM
  • T-reg: 15 nTPM

Brain region

  • cerebral cortex: 56 nTPM
  • pons: 47 nTPM
  • cerebellum: 46 nTPM
  • white matter: 44 nTPM
  • medulla oblongata: 44 nTPM
  • thalamus: 43 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ATP5PB.

Disease | ImmuneIEDB

Conditions an epitope on ATP5PB was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
DepMap mean gene effect
-0.65
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • ATP synthase, F0 complex, subunit B/MI25
  • ATP synthase, F0 complex, subunit B
  • Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATP5PB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP5PB as an antibody target. Whether an autoantibody or antibody against ATP5PB could matter depends on whether native ATP5PB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP5PB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATP5PB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ATP5PB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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