Seroatlas · Human Serome Atlas

ATP5PD

ATP synthase peripheral stalk subunit d, mitochondrial

Also known as: ATP5H, ATP5H_HUMAN, ATP5JD, ATPQ

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75947
Gene
ATP5PD
Ensembl
ENSG00000167863
Chromosome
17
Canonical length
161 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Transporters
Subcellular location
Mitochondria
Quaternary structure
Homooctamer

OverviewNCBI Gene

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

161 residues, UniProt reviewed canonical sequence.

>O75947|ATP5PD
     1  MAGRKLALKT IDWVAFAEII PQNQKAIASS LKSWNETLTS RLAALPENPP AIDWAYYKAN
    61  VAKAGLVDDF EKKFNALKVP VPEDKYTAQV DAEEKEDVKS CAEWVSLSKA RIVEYEKEME
   121  KMKNLIPFDQ MTIEDLNEAF PETKLDKKKY PYWPHQPIEN L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP5PD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
1,034 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 1,034 nTPM
  • tongue: 956 nTPM
  • heart muscle: 923 nTPM
  • choroid plexus: 451 nTPM
  • kidney: 447 nTPM
  • liver: 424 nTPM

Single-cell type

  • esophageal suprabasal cells: 1,019 nCPM
  • parietal cells: 937 nCPM
  • esophageal apical cells: 936 nCPM
  • esophageal basal cells: 687 nCPM
  • hofbauer cells: 630 nCPM
  • enterocytes: 517 nCPM

Immune cell

  • intermediate monocyte: 542 nTPM
  • myeloid DC: 511 nTPM
  • total PBMC: 497 nTPM
  • T-reg: 494 nTPM
  • eosinophil: 483 nTPM
  • memory CD4 T-cell: 469 nTPM

Brain region

  • choroid plexus: 184 nTPM
  • hypothalamus: 159 nTPM
  • cerebellum: 156 nTPM
  • medulla oblongata: 145 nTPM
  • cerebral cortex: 142 nTPM
  • thalamus: 138 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.39
gnomAD pLI
0
DepMap mean gene effect
-0.49
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • ATP synthase, F0 complex, subunit D, mitochondrial
  • ATP synthase, F0 complex, subunit D superfamily, mitochondrial
  • ATP synthase D chain, mitochondrial (ATP5H)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATP5PD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP5PD as an antibody target. Whether an autoantibody or antibody against ATP5PD could matter depends on whether native ATP5PD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP5PD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATP5PD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ATP5PD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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