ATP5F1C

Protein identityUniProt · HPA

UniProt accession

P36542

Gene

ATP5F1C

Ensembl

ENSG00000165629

Chromosome

10

Canonical length

298 aa

Protein class

Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters

Quaternary structure

Homooctamer

OverviewNCBI Gene

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>P36542|ATP5F1C
     1  MFSRAGVAGL SAWTLQPQWI QVRNMATLKD ITRRLKSIKN IQKITKSMKM VAAAKYARAE
    61  RELKPARIYG LGSLALYEKA DIKGPEDKKK HLLIGVSSDR GLCGAIHSSI AKQMKSEVAT
   121  LTAAGKEVML VGIGDKIRGI LYRTHSDQFL VAFKEVGRKP PTFGDASVIA LELLNSGYEF
   181  DEGSIIFNKF RSVISYKTEE KPIFSLNTVA SADSMSIYDD IDADVLQNYQ EYNLANIIYY
   241  SLKESTTSEQ SARMTAMDNA SKNASEMIDK LTLTFNRTRQ AVITKELIEI ISGAAALD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP5F1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

835 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.81

gnomAD pLI

0

DepMap mean gene effect

-0.56

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ATP biosynthetic process
• oxidative phosphorylation
• proton motive force-driven ATP synthesis
• proton motive force-driven mitochondrial ATP synthesis

Molecular functions

• proton-transporting ATP synthase activity, rotational mechanism
• RNA binding

Cellular components

• membrane
• mitochondrial inner membrane
• mitochondrial matrix
• mitochondrion
• proton-transporting ATP synthase complex

Protein domainsUniProt · Pfam · InterPro

• ATP synthase, F1 complex, gamma subunit
• ATP synthase, F1 complex, gamma subunit conserved site
• ATP synthase, F1 complex, gamma subunit superfamily
• ATP synthase

KeywordsUniProt

• Acetylation
• ATP synthesis
• CF(1)
• Hydrogen ion transport
• Ion transport
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Phosphoprotein
• Transit peptide
• Transport

InteractionsUniProt · HPA

Protein binding partners of ATP5F1C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FLVCR2
• ATP5F1B
• ATP5PB