ATP5MG

Protein identityUniProt · HPA

UniProt accession

O75964

Gene

ATP5MG

Ensembl

ENSG00000167283

Chromosome

11

Canonical length

103 aa

Protein class

Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Subcellular location

Mitochondria,Principal piece

Quaternary structure

Homooctamer

OverviewNCBI Gene

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

103 residues, UniProt reviewed canonical sequence.

>O75964|ATP5MG
     1  MAQFVRNLVE KTPALVNAAV TYSKPRLATF WYYAKVELVP PTPAEIPRAI QSLKKIVNSA
    61  QTGSFKQLTV KEAVLNGLVA TEVLMWFYVG EIIGKRGIIG YDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP5MG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

351 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.55

gnomAD pLI

0

DepMap mean gene effect

-0.33

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• proton motive force-driven ATP synthesis
• proton motive force-driven mitochondrial ATP synthesis

Molecular functions

• proton transmembrane transporter activity

Cellular components

• mitochondrial inner membrane
• mitochondrion
• proton-transporting ATP synthase complex
• sperm principal piece

Protein domainsUniProt · Pfam · InterPro

• ATP synthase F0 complex subunit G, mitochondrial
• ATP synthase, F0 complex, gamma subunit, metazoa
• Mitochondrial ATP synthase g subunit

KeywordsUniProt

• Acetylation
• ATP synthesis
• CF(0)
• Hydrogen ion transport
• Ion transport
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Transport

InteractionsUniProt · HPA

Protein binding partners of ATP5MG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATP5PB