ATP5PF

Protein identityUniProt · HPA

UniProt accession

P18859

Gene

ATP5PF

Ensembl

ENSG00000154723

Chromosome

21

Canonical length

108 aa

Protein class

Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters

Subcellular location

Mitochondria,Flagellar centriole,End piece

Quaternary structure

Homooctamer

OverviewNCBI Gene

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo complex has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex. The F6 subunit is required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has 1 or more pseudogenes. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>P18859|ATP5PF
     1  MILQRLFRFS SVIRSAVSVH LRRNIGVTAV AFNKELDPIQ KLFVDKIREY KSKRQTSGGP
    61  VDASSEYQQE LERELFKLKQ MFGNADMNTF PTFKFEDPKF EVIEKPQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP5PF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.56

Highest tissue expression

1,487 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ATP5PF.

Disease | ImmuneIEDB

Conditions an epitope on ATP5PF was assayed in.

• sarcoidosis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.43

gnomAD pLI

0.01

DepMap mean gene effect

-0.35

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• proton motive force-driven ATP synthesis
• proton motive force-driven mitochondrial ATP synthesis
• substantia nigra development

Molecular functions

• proton transmembrane transporter activity

Cellular components

• centriole
• mitochondrial inner membrane
• mitochondrion
• proton-transporting ATP synthase complex
• sperm end piece

Protein domainsUniProt · Pfam · InterPro

• ATP synthase-coupling factor 6, mitochondrial
• ATP synthase-coupling factor 6 superfamily, mitochondrial
• Mitochondrial ATP synthase coupling factor 6

KeywordsUniProt

• Acetylation
• CF(0)
• Hydrogen ion transport
• Ion transport
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Phosphoprotein
• Transit peptide
• Transport

InteractionsUniProt · HPA

Protein binding partners of ATP5PF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATP5F1A
• ATP5F1B
• ATP5F1D
• ATP5ME
• ATP5PB
• ATP5PD
• ATP5PO
• SLC19A2
• SLC38A1
• UNC93B1