Seroatlas · Human Serome Atlas

METTL15

12S rRNA N(4)-cytidine methyltransferase METTL15

Also known as: FLJ33979, MET15_HUMAN, METT5D1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NJ78
Gene: METTL15
Ensembl: ENSG00000169519
Chromosome: 11
Canonical length: 407 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables rRNA (cytosine-N4-)-methyltransferase activity. Involved in rRNA base methylation. Is active in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>A6NJ78|METTL15
     1  MLRYPYFCRM YKECLSCWLE SGIPNLGVWP NRIHTTAEKY REYEAREQTD QTQAQELHRS
    61  QDRDFETMAK LHIPVMVDEV VHCLSPQKGQ IFLDMTFGSG GHTKAILQKE SDIVLYALDR
   121  DPTAYALAEH LSELYPKQIR AMLGQFSQAE ALLMKAGVQP GTFDGVLMDL GCSSMQLDTP
   181  ERGFSLRKDG PLDMRMDGGR YPDMPTAADV VNALDQQALA SILRTYGEEK HAKKIASAIV
   241  QARSIYPITR TQQLASIVAG AFPPSAIYTR KDLLQRSTHI ATKTFQALRI FVNNELNELY
   301  TGLKTAQKFL RPGGRLVALS FHSLEDRIVK RFLLGISMTE RFNLSVRQQV MKTSQLGSDH
   361  ENTEEVSMRR APLMWELIHK KVLSPQDQDV QDNPRGRSAK LRAAIKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

tongue: 10 nTPM
liver: 8.7 nTPM
skeletal muscle: 8.2 nTPM
adrenal gland: 7.6 nTPM
heart muscle: 7.2 nTPM
kidney: 7.2 nTPM

Single-cell type

choroid plexus epithelial cells: 373 nCPM
ependymal cells: 365 nCPM
lactotrophs: 344 nCPM
pituicytes/fscs: 318 nCPM
thyrotrophs: 308 nCPM
corticotrophs: 303 nCPM

Immune cell

NK-cell: 4.4 nTPM
eosinophil: 3.7 nTPM
memory B-cell: 3.6 nTPM
naive CD8 T-cell: 3.6 nTPM
T-reg: 3.1 nTPM
memory CD8 T-cell: 2.9 nTPM

Brain region

choroid plexus: 18 nTPM
white matter: 17 nTPM
cerebellum: 16 nTPM
hypothalamus: 16 nTPM
cerebral cortex: 16 nTPM
pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: -0.24
DepMap mean gene effect: -0.4
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

rRNA (cytosine-N4-)-methyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of METTL15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL15 as an antibody target. Whether an autoantibody or antibody against METTL15 could matter depends on whether native METTL15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METTL15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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