ATP5ME

Protein identityUniProt · HPA

UniProt accession

P56385

Gene

ATP5ME

Ensembl

ENSG00000169020

Chromosome

4

Canonical length

69 aa

Protein class

Metabolic proteins, Predicted intracellular proteins, Transporters

Subcellular location

Mitochondria

Quaternary structure

Homooctamer

OverviewNCBI Gene

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

69 residues, UniProt reviewed canonical sequence.

>P56385|ATP5ME
     1  MVPPVQVSPL IKLGRYSALF LGVAYGATRY NYLKPRAEEE RRIAAEEKKK QDELKRIARE
    61  LAEDDSILK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP5ME can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

2,121 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ATP5ME.

Disease | ImmuneIEDB

Conditions an epitope on ATP5ME was assayed in.

• sarcoidosis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.37

gnomAD pLI

0.09

DepMap mean gene effect

-0.43

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• proton motive force-driven ATP synthesis
• proton motive force-driven mitochondrial ATP synthesis

Molecular functions

• protein-containing complex binding
• proton transmembrane transporter activity

Cellular components

• mitochondrial inner membrane
• mitochondrion
• proton-transporting ATP synthase complex

Protein domainsUniProt · Pfam · InterPro

• ATP synthase, F0 complex, subunit E, mitochondrial
• ATP synthase E chain

KeywordsUniProt

• Acetylation
• ATP synthesis
• CF(0)
• Hydrogen ion transport
• Ion transport
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Phosphoprotein
• Transport

InteractionsUniProt · HPA

Protein binding partners of ATP5ME in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATP5PB
• ATP5PF